BCL6 Antikörper (AA 256-389) (CF®640R)
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- Target Alle BCL6 Antikörper anzeigen
- BCL6 (B-Cell CLL/lymphoma 6 (BCL6))
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Bindungsspezifität
- AA 256-389
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Reaktivität
- Human
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser BCL6 Antikörper ist konjugiert mit CF®640R
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Applikation
- Flow Cytometry (FACS), Immunohistochemistry (IHC), Immunofluorescence (IF)
- Verwendungszweck
- Mouse Monoclonal anti-Bcl-6 (BCL6/1527), CF640R Conjugate
- Produktmerkmale
- This antibody recognizes a protein of 95 kDa, which is identified as Bcl-6. Antibody to bcl-6 is helpful in a number of diagnostic settings: (1) In the differential diagnosis of small B-cell lymphoma. Follicular lymphoma will show bcl-6 (and CD10) positivity whereas other small B-cell lymphomas are usually negative. (2) Bcl-6 is an important prognostic marker in diffuse large B-cell lymphomas (DLBCL), where CD10, bcl-6 and MUM1/IRF4 are used to identify germinal center and activated B-cell phenotypes. (3) Bcl-6 can be valuable in distinguishing classical Hodgkin lymphoma from nodular lymphocyte predominant Hodgkin lymphoma (NLPHL). The Reed-Sternberg cells of classical Hodgkin lymphoma are bcl-6 negative whereas the large ( L&H ) cells of NLPHL are bcl-6 positive. In contrast, anti-Bcl-6 rarely stains mantle-cell lymphoma and MALT lymphoma. Primary antibodies are available purified, or with a selection of fluorescent CF® dyes and other labels. CF® dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
- Immunogen
- Recombinant human bcl-6 protein fragment (aa256-389) (exact sequence is proprietary)
- Klon
- BCL6-1527
- Isotyp
- IgG1 kappa
- Top Product
- Discover our top product BCL6 Primärantikörper
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- Applikationshinweise
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Immunohistology (formalin) 1-2 μg/mL
- Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM Tris, 1 mM EDTA pH 9.0 for 10-20 min followed by cooling at RT for 20 min
- Flow Cytometry 0.5-1 μg/million cells/0.1 mL
- Immunofluorescence 1-2 μg/mL
- Optimal dilution for a specific application should be determined by user
- Kommentare
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Raji or Ramos cells. Tonsil or Hodgkin s lymphoma.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 100 μg/mL
- Buffer
- PBS/0.1 % BSA/0.05 % azide
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Protect from light
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- Target
- BCL6 (B-Cell CLL/lymphoma 6 (BCL6))
- Andere Bezeichnung
- Bcl-6 (BCL6 Produkte)
- Synonyme
- bcl5 antikoerper, laz3 antikoerper, bcl6a antikoerper, znf51 antikoerper, zbtb27 antikoerper, MGC132260 antikoerper, Bcl5 antikoerper, BCL5 antikoerper, BCL6A antikoerper, LAZ3 antikoerper, ZBTB27 antikoerper, ZNF51 antikoerper, B-cell CLL/lymphoma 6 L homeolog antikoerper, B-cell CLL/lymphoma 6 antikoerper, B cell leukemia/lymphoma 6 antikoerper, bcl6.L antikoerper, bcl6 antikoerper, BCL6 antikoerper, Bcl6 antikoerper
- Molekulargewicht
- 95 kDa
- Gen-ID
- 604, 478588
- UniProt
- P41182
- Pathways
- Chromatin Binding, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Protein targeting to Nucleus
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