CFTR Antikörper

Produktnummer ABIN6174638

Produktdetails anti-CFTR Antikörper

Target: CFTR (Cystic Fibrosis Transmembrane Conductance Regulator (ATP-Binding Cassette Sub-Family C, Member 7) (CFTR))

Reaktivität: Human, Maus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CFTR Antikörper ist unkonjugiert

Applikation: Immunofluorescence (IF), Immunohistochemistry (IHC), Immunostaining (ISt), Western Blotting (WB)

Verwendungszweck: Mouse Monoclonal anti-CFTR CFTR/1342), Purified, with BSA

Produktmerkmale: This antibody recognizes a protein of 165-170 kDa, identified as cystic fibrosis transmembrane conductance regulator (CFTR). CFTR is composed of two membrane-spanning domains (MSD), two nucleotide-binding domains (NBD), and an R domain. It is structurally similar to multidrug resistance (Mdr1) protein and both are members of the superfamily of ATP-binding cassette (ABC) transporters, also known as traffic ATPases, which are implicated in the movement of various substrates. The CFTR protein is a small conductance adenosine 3',5'-cyclic monophosphate (cAMP)-activated chloride ion channel found in the apical membranes of epithelia within the pancreas, airway, intestine, bile duct, sweat gland, and male genital ducts. CFTR is a valuable marker of human pancreatic duct cell development and differentiation. Primary antibodies are available purified, or with a selection of fluorescent CF® dyes and other labels. CF® dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Aufreinigung: Purified

Immunogen: Recombinant human full-length CFTR

Klon: CFTR-1342

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: Immunohistology (formalin) 0.5-1 μg/mL

• Staining of formalin-fixed tissues is enhanced by boiling tissue sections in 10 mM Tris, 1 mM EDTA  pH 9.0 for 10-20 min followed by cooling at RT for 20 min
• Immunofluorescence 0.5-1 μg/mL
• Western blotting 0.5-1 μg/mL
• Optimal dilution for a specific application should be determined by user

Kommentare:

MOLT-4 cells. Pancreas, Kidney or Placenta.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 200 μg/mL

Buffer: PBS/0.05 % BSA/0.05 % azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Details zu CFTR

Target: CFTR (Cystic Fibrosis Transmembrane Conductance Regulator (ATP-Binding Cassette Sub-Family C, Member 7) (CFTR))

Andere Bezeichnung: CFTR (CFTR Produkte)

Synonyme: ABC35 antikoerper, ABCC7 antikoerper, CF antikoerper, CFTR/MRP antikoerper, MRP7 antikoerper, TNR-CFTR antikoerper, dJ760C5.1 antikoerper, CFTR antikoerper, AW495489 antikoerper, Abcc7 antikoerper, RGD1561193 antikoerper, abc35 antikoerper, abcc7 antikoerper, cftr/mrp antikoerper, mrp7 antikoerper, tnr-cftr antikoerper, xcftr antikoerper, si:dkey-270i2.2 antikoerper, cystic fibrosis transmembrane conductance regulator antikoerper, cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) antikoerper, CFTR antikoerper, cftr-A antikoerper, Cftr antikoerper, cftr antikoerper

Molekulargewicht: 165-170 kDa

Gen-ID: 1080