CCR5 Antikörper (CF®647)
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- Target Alle CCR5 Antikörper anzeigen
- CCR5 (Chemokine (C-C Motif) Receptor 5 (CCR5))
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Reaktivität
- Human
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser CCR5 Antikörper ist konjugiert mit CF®647
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Applikation
- Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro))
- Verwendungszweck
- Mouse Monoclonal anti-CD195 / CCR-5 (12D1), CF647 Conjugate
- Produktmerkmale
- This antibody reacts with the N-terminal extracellular domain of CD195. The CC chemokine receptor 5 (CCR5) is a member of the CC-chemokine receptor family, and has the characteristic structure of a 7 transmembrane G protein-coupled receptor (GPCR). CCR5 regulates trafficking and effector functions of memory/effector Th1 cells, macrophages, NK cells, and immature dendritic cells. CCR5 and its ligands play an important role in viral pathogenesis. CCR5 represents the co-receptor for macrophage (M) and dual (T cell and M)-tropic immunodeficiency viruses. Together with the CD4 binding receptor, CCR5 plays a critical role in HIV entry into the target cells. Moreover, the CCR5 ligands macrophage inflammatory protein (MIP)-1 alpha, MIP-1 beta and RANTES act as endogenous inhibitors of HIV infection, making both CCR5 and its chemokine ligands attractive therapeutic targets for HIV infection. Recent studies have also highlighted the role of CCR5 in a variety of other human diseases, ranging from infectious and inflammatory diseases to cancer. Primary antibodies are available purified, or with a selection of fluorescent CF® dyes and other labels. CF® dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
- Immunogen
- Human native CCR5 protein
- Klon
- 12D1-
- Isotyp
- IgG2a kappa
- Top Product
- Discover our top product CCR5 Primärantikörper
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- Applikationshinweise
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Immunofluorescence 0.5-1 μg/mL Immunohistology Frozen 0.5-1.0 μg/mL
- Flow Cytometry 0.5-1 μg/million cells/0.1 mL
- Optimal dilution for a specific application should be determined by user
- Kommentare
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Human lymph node and tonsil.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 100 μg/mL
- Buffer
- PBS/0.1 % BSA/0.05 % azide
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Protect from light
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- Target
- CCR5 (Chemokine (C-C Motif) Receptor 5 (CCR5))
- Andere Bezeichnung
- CD195 / CCR-5 (CCR5 Produkte)
- Synonyme
- CC-CKR-5 antikoerper, CCCKR5 antikoerper, CCR-5 antikoerper, CD195 antikoerper, CKR-5 antikoerper, CKR5 antikoerper, CMKBR5 antikoerper, IDDM22 antikoerper, Ckr5 antikoerper, Cmkbr5 antikoerper, CCR1-L antikoerper, GPCR antikoerper, CCR5 antikoerper, AM4-7 antikoerper, C-C motif chemokine receptor 5 (gene/pseudogene) antikoerper, chemokine (C-C motif) receptor 5 antikoerper, C-C motif chemokine receptor 5 antikoerper, CCR5 antikoerper, Ccr5 antikoerper
- Hintergrund
- CC Chemokine Receptor Type 5, CC-CKR-5, CCCKR5, CCR5, Chemokine CC motif receptor 5, Chemokine receptor CCR5, CHEMR13, CKR5, CMKBR5, HIV-1 fusion coreceptor, IDDM22, MIP-1 alpha receptor
- Molekulargewicht
- 45 kDa
- Gen-ID
- 1234, 450802
- UniProt
- P51681
- Pathways
- Cellular Response to Molecule of Bacterial Origin, cAMP Metabolic Process, Regulation of Cell Size
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