NPC1L1 Antikörper (AA 1030-1100)

Produktnummer ABIN6144760

Produktdetails anti-NPC1L1 Antikörper

Target: NPC1L1 (NPC1 (Niemann-Pick Disease, Type C1, Gene)-Like 1 (NPC1L1))

Bindungsspezifität: AA 1030-1100

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NPC1L1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: AAYSTSVNLT SDGQVLASRF MAYHKPLKNS QDYTEALRAA RELAANITAD LRKVPGTDPA FEVFPYTITN V

Kreuzreaktivität: Human

Produktmerkmale: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1030-1100 of human NPC1L1 (NP_001095118.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:1000 - 1:4000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu NPC1L1

Target: NPC1L1 (NPC1 (Niemann-Pick Disease, Type C1, Gene)-Like 1 (NPC1L1))

Andere Bezeichnung: NPC1L1 (NPC1L1 Produkte)

Synonyme: NPC1L1 antikoerper, 9130221N23Rik antikoerper, Gm243 antikoerper, NPC11L1 antikoerper, NPC1 like intracellular cholesterol transporter 1 antikoerper, NPC1 like 1 antikoerper, NPC1-like 1 antikoerper, NPC1L1 antikoerper, npc1l1 antikoerper, Npc1l1 antikoerper

Hintergrund: The protein encoded by this gene is a multi-pass membrane protein. It contains a conserved N-terminal Niemann-Pick C1 (NPC1) domain and a putative sterol-sensing domain (SSD) which includes a YQRL motif functioning as a plasma membrane to trans-Golgi network transport signal in other proteins. This protein takes up free cholesterol into cells through vesicular endocytosis and plays a critical role in the absorption of intestinal cholesterol. It also has the ability to transport alpha-tocopherol (vitamin E). The drug ezetimibe targets this protein and inhibits the absorption of intestinal cholesterol and alpha-tocopherol. In addition, this protein may play a critical role in regulating lipid metabolism. Polymorphic variations in this gene are associated with plasma total cholesterol and low-density lipoprotein cholesterol (LDL-C) levels and coronary heart disease (CHD) risk. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.,NPC1L1,NPC11L1,Cancer,Signal Transduction,Endocrine & Metabolism,Lipid Metabolism,Cholesterol Metabolism,Neuroscience,Cardiovascular,Heart,Lipids,Cardiovascular diseases,Heart disease,NPC1L1

Molekulargewicht: 79 kDa/140 kDa/145 kDa/148 kDa

Gen-ID: 29881

UniProt: Q9UHC9