NPC1L1
Reaktivität: Human
WB, IP
Wirt: Kaninchen
Polyclonal
unconjugated
Applikationshinweise
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:50-1:100) Western Blot (1:500) The optimal working dilution should be determined by the end user.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Liquid
Buffer
In PBS (0.02 % sodium azide)
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
4 °C
Informationen zur Lagerung
Store at 4°C. Do not freeze.
Infante, Abi-Mosleh, Radhakrishnan, Dale, Brown, Goldstein: "Purified NPC1 protein. I. Binding of cholesterol and oxysterols to a 1278-amino acid membrane protein." in: The Journal of biological chemistry, Vol. 283, Issue 2, pp. 1052-63, (2008) (PubMed).
Montoudis, Seidman, Boudreau, Beaulieu, Menard, Elchebly, Mailhot, Sane, Lambert, Delvin, Levy: "Intestinal fatty acid binding protein regulates mitochondrion beta-oxidation and cholesterol uptake." in: Journal of lipid research, Vol. 49, Issue 5, pp. 961-72, (2008) (PubMed).
Liu, Mani, Davis, Sarrafzadegan, Kavathas, Mani: "Mutation in EGFP domain of LDL receptor-related protein 6 impairs cellular LDL clearance." in: Circulation research, Vol. 103, Issue 11, pp. 1280-8, (2008) (PubMed).
Nauli, Nassir, Zheng, Yang, Lo, Vonlehmden, Lee, Jandacek, Abumrad, Tso: "CD36 is important for chylomicron formation and secretion and may mediate cholesterol uptake in the proximal intestine." in: Gastroenterology, Vol. 131, Issue 4, pp. 1197-207, (2006) (PubMed).
Target
NPC1L1
(NPC1 (Niemann-Pick Disease, Type C1, Gene)-Like 1 (NPC1L1))