Rekombinanter NPC1L1 Antikörper
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- Target Alle NPC1L1 Antikörper anzeigen
- NPC1L1 (NPC1 (Niemann-Pick Disease, Type C1, Gene)-Like 1 (NPC1L1))
- Antikörpertyp
- Recombinant Antibody
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Monoklonal
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Konjugat
- Dieser NPC1L1 Antikörper ist unkonjugiert
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Applikation
- ELISA, Immunohistochemistry (IHC)
- Kreuzreaktivität
- Human
- Aufreinigung
- Affinity-chromatography
- Immunogen
- A synthesized peptide derived from human NPC1L1
- Klon
- 4B10
- Isotyp
- IgG
- Top Product
- Discover our top product NPC1L1 Primärantikörper
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- Applikationshinweise
- Recommended dilution: IHC:1:50-1:200,
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Buffer
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C,-80 °C
- Informationen zur Lagerung
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Target
- NPC1L1 (NPC1 (Niemann-Pick Disease, Type C1, Gene)-Like 1 (NPC1L1))
- Andere Bezeichnung
- NPC1L1 (NPC1L1 Produkte)
- Synonyme
- NPC1L1 antikoerper, 9130221N23Rik antikoerper, Gm243 antikoerper, NPC11L1 antikoerper, NPC1 like intracellular cholesterol transporter 1 antikoerper, NPC1 like 1 antikoerper, NPC1-like 1 antikoerper, NPC1L1 antikoerper, npc1l1 antikoerper, Npc1l1 antikoerper
- Hintergrund
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Background: Plays a major role in cholesterol homeostasis. Is critical for the uptake of cholesterol across the plasma membrane of the intestinal enterocyte. Is the direct molecular target of ezetimibe, a drug that inhibits cholesterol absorption. Lack of activity leads to multiple lipid transport defects. The protein may have a function in the transport of multiple lipids and their homeostasis, and may play a critical role in regulating lipid metabolism. Acts as a negative regulator of NPC2 and down-regulates its expression and secretion by inhibiting its maturation and accelerating its degradation.
Aliases: NPC1-like intracellular cholesterol transporter 1 (Niemann-Pick C1-like protein 1), NPC1L1
- UniProt
- Q9UHC9
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