PIEZO1 Antikörper

Produktnummer ABIN5705358

Produktdetails anti-PIEZO1 Antikörper

Target: PIEZO1 (Piezo-Type Mechanosensitive Ion Channel Component 1 (PIEZO1))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PIEZO1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Immunogen: family with sequence similarity 38, member A

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB : 1:200-1:1000 IHC : 1:50-1:500

Kommentare:

HepG2 cells were subjected to SDS PAGE followed by western blot with FNab06435(Piezo1 antibody) at dilution of 1:500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Haltbarkeit: 12 months

Details zu PIEZO1

Target: PIEZO1 (Piezo-Type Mechanosensitive Ion Channel Component 1 (PIEZO1))

Andere Bezeichnung: Piezo1 (PIEZO1 Produkte)

Synonyme: DHS antikoerper, FAM38A antikoerper, Mib antikoerper, 9630020g22 antikoerper, Fam38a antikoerper, mKIAA0233 antikoerper, piezo type mechanosensitive ion channel component 1 antikoerper, piezo-type mechanosensitive ion channel component 1 antikoerper, PIEZO1 antikoerper, Piezo1 antikoerper

Hintergrund: Synonyms:FAM38A, KIAA0233 Background:Pore-forming subunit of a mechanosensitive non-specific cation channel(PubMed:23479567, PubMed:23695678). Generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling(PubMed:20016066). In the kidney, may contribute to the detection of intraluminal pressure changes and to urine flow sensing. Acts as shear-stress sensor that promotes endothelial cell organization and alignment in the direction of blood flow through calpain activation(PubMed:25119035). Plays a key role in blood vessel formation and vascular structure in both development and adult physiology(By similarity).

Molekulargewicht: 250 kDa

Gen-ID: 9780

UniProt: Q92508