PIEZO1 Antikörper (Internal Region)

Produktnummer ABIN6264200

Produktdetails anti-PIEZO1 Antikörper

Target: PIEZO1 (Piezo-Type Mechanosensitive Ion Channel Component 1 (PIEZO1))

Bindungsspezifität: Internal Region

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PIEZO1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Spezifität: Piezo1 Antibody detects endogenous levels of total Piezo1.

Homologie: Pig,Bovine,Horse,Dog,Chicken,Xenopus

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human Piezo1, corresponding to a region within the internal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu PIEZO1

Target: PIEZO1 (Piezo-Type Mechanosensitive Ion Channel Component 1 (PIEZO1))

Andere Bezeichnung: PIEZO1 (PIEZO1 Produkte)

Synonyme: DHS antikoerper, FAM38A antikoerper, Mib antikoerper, 9630020g22 antikoerper, Fam38a antikoerper, mKIAA0233 antikoerper, piezo type mechanosensitive ion channel component 1 antikoerper, piezo-type mechanosensitive ion channel component 1 antikoerper, PIEZO1 antikoerper, Piezo1 antikoerper

Hintergrund:

Description: Pore-forming subunit of a mechanosensitive non-specific cation channel (PubMed:23479567, PubMed:23695678). Generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling (PubMed:20016066). In the kidney, may contribute to the detection of intraluminal pressure changes and to urine flow sensing. Acts as shear-stress sensor that promotes endothelial cell organization and alignment in the direction of blood flow through calpain activation (PubMed:25119035). Plays a key role in blood vessel formation and vascular structure in both development and adult physiology (By similarity).

Gene: PIEZO1

Molekulargewicht: 287 kDa

Gen-ID: 9780

UniProt: Q92508