PIEZO1 Antikörper (AA 2230-2420)

Produktnummer ABIN7163444

Produktdetails anti-PIEZO1 Antikörper

Target: PIEZO1 (Piezo-Type Mechanosensitive Ion Channel Component 1 (PIEZO1))

Bindungsspezifität: AA 2230-2420

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PIEZO1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), ELISA

Kreuzreaktivität: Human

Aufreinigung: Antigen Affinity Purified

Immunogen: Recombinant Human Piezo-type mechanosensitive ion channel component 1 protein (2230-2420AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:20-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu PIEZO1

Target: PIEZO1 (Piezo-Type Mechanosensitive Ion Channel Component 1 (PIEZO1))

Andere Bezeichnung: PIEZO1 (PIEZO1 Produkte)

Synonyme: DHS antikoerper, FAM38A antikoerper, Mib antikoerper, 9630020g22 antikoerper, Fam38a antikoerper, mKIAA0233 antikoerper, piezo type mechanosensitive ion channel component 1 antikoerper, piezo-type mechanosensitive ion channel component 1 antikoerper, PIEZO1 antikoerper, Piezo1 antikoerper

Hintergrund:

Background: Pore-forming subunit of a mechanosensitive non-specific cation channel (PubMed:23479567, PubMed:23695678). Generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling (PubMed:20016066). In the kidney, may contribute to the detection of intraluminal pressure changes and to urine flow sensing. Acts as shear-stress sensor that promotes endothelial cell organization and alignment in the direction of blood flow through calpain activation (PubMed:25119035). Plays a key role in blood vessel formation and vascular structure in both development and adult physiology (By similarity).

Aliases: DHS antibody, Fam38a antibody, Family with sequence similarity 38 member A antibody, KIAA0233 antibody, Membrane protein induced by beta-amyloid treatment antibody, Mib antibody, PIEZ1_HUMAN antibody, Piezo-type mechanosensitive ion channel component 1 antibody, PIEZO1 antibody, Protein FAM38A antibody, Protein FAM38B antibody, Protein PIEZO1 antibody

UniProt: Q92508