EPH Receptor A7 Antikörper

Produktnummer ABIN5703804

Produktdetails anti-EPH Receptor A7 Antikörper

Target: EPH Receptor A7 (EPHA7)

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser EPH Receptor A7 Antikörper ist unkonjugiert

Applikation: ELISA

Immunogen: EPH receptor A7

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Haltbarkeit: 12 months

Details zu EPH Receptor A7

Target: EPH Receptor A7 (EPHA7)

Andere Bezeichnung: EPHA7 (EPHA7 Produkte)

Synonyme: fc51g03 antikoerper, wu:fc51g03 antikoerper, si:dkey-23k6.1 antikoerper, EHK3 antikoerper, HEK11 antikoerper, Cek11 antikoerper, Ebk antikoerper, Ehk3 antikoerper, Hek11 antikoerper, Mdk1 antikoerper, CEPHA7 antikoerper, EPH receptor A7 antikoerper, eph receptor A7 antikoerper, ephrin type-B receptor 1-B antikoerper, Eph receptor A7 antikoerper, EPHA7 antikoerper, epha7 antikoerper, LOC100166161 antikoerper, Epha7 antikoerper

Hintergrund: Synonyms:EHK3, HEK11 Background:Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7 and their interaction regulates brain development modulating cell-cell adhesion and repulsion. Has a repellent activity on axons and is for instance involved in the guidance of corticothalamic axons and in the proper topographic mapping of retinal axons to the colliculus. May also regulate brain development through a caspase(CASP3)-dependent proapoptotic activity. Forward signaling may result in activation of components of the ERK signaling pathway including MAP2K1, MAP2K2, MAPK1 AND MAPK3 which are phosphorylated upon activation of EPHA7.

Gen-ID: 2045

UniProt: Q15375

Pathways: RTK Signalweg