EPH Receptor A7 Antikörper (AA 28-182)

Produktnummer ABIN7151851

Produktdetails anti-EPH Receptor A7 Antikörper

Target: EPH Receptor A7 (EPHA7)

Bindungsspezifität: AA 28-182

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser EPH Receptor A7 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Ephrin type-A receptor 7 protein (28-182AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:500,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu EPH Receptor A7

Target: EPH Receptor A7 (EPHA7)

Andere Bezeichnung: EPHA7 (EPHA7 Produkte)

Synonyme: fc51g03 antikoerper, wu:fc51g03 antikoerper, si:dkey-23k6.1 antikoerper, EHK3 antikoerper, HEK11 antikoerper, Cek11 antikoerper, Ebk antikoerper, Ehk3 antikoerper, Hek11 antikoerper, Mdk1 antikoerper, CEPHA7 antikoerper, EPH receptor A7 antikoerper, eph receptor A7 antikoerper, ephrin type-B receptor 1-B antikoerper, Eph receptor A7 antikoerper, EPHA7 antikoerper, epha7 antikoerper, LOC100166161 antikoerper, Epha7 antikoerper

Hintergrund:

Background: Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7 and their interaction regulates brain development modulating cell-cell adhesion and repulsion. Has a repellent activity on axons and is for instance involved in the guidance of corticothalamic axons and in the proper topographic mapping of retinal axons to the colliculus. May also regulate brain development through a caspase(CASP3)-dependent proapoptotic activity. Forward signaling may result in activation of components of the ERK signaling pathway including MAP2K1, MAP2K2, MAPK1 AND MAPK3 which are phosphorylated upon activation of EPHA7.

Aliases: Cek 11 antibody, Developmental kinase 1 antibody, EBK antibody, EHK-3 antibody, EHK3 antibody, EK11 antibody, Embryonic brain kinase antibody, EPH homology kinase 3 antibody, EPH-like kinase 11 antibody, Epha7 antibody, EPHA7_HUMAN antibody, Ephrin receptor Eph A7 antibody, Ephrin type A receptor 7 antibody, Ephrin type-A receptor 7 antibody, hEK11 antibody, MDK 1 antibody, Receptor protein tyrosine kinase HEK 11 antibody, Tyrosine protein kinase receptor EHK 3 antibody

UniProt: Q15375

Pathways: RTK Signalweg