HMGB2 Antikörper
-
- Target Alle HMGB2 Antikörper anzeigen
- HMGB2 (High Mobility Group Box 2 (HMGB2))
-
Reaktivität
- Human, Maus, Ratte
-
Wirt
- Kaninchen
-
Klonalität
- Polyklonal
-
Konjugat
- Dieser HMGB2 Antikörper ist unkonjugiert
-
Applikation
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP)
- Immunogen
- high-mobility group box 2
- Isotyp
- IgG
- Top Product
- Discover our top product HMGB2 Primärantikörper
-
-
- Applikationshinweise
- Optimal working dilution should be determined by the investigator.
- Kommentare
-
Jurkat cells were subjected to SDS PAGE followed by western blot with FNab03925(HMGB2 antibody) at dilution of 1:600
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
- Buffer
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freeze / thaw cycles.
- Lagerung
- -20 °C
- Haltbarkeit
- 12 months
-
- Target
- HMGB2 (High Mobility Group Box 2 (HMGB2))
- Andere Bezeichnung
- HMGB2 (HMGB2 Produkte)
- Synonyme
- HMG2 antikoerper, C80539 antikoerper, HMG-2 antikoerper, Hmg2 antikoerper, HIGH MOBILITY GROUP BETA 1 antikoerper, HMG BETA 1 antikoerper, NFD02 antikoerper, NFD2 antikoerper, NUCLEOSOME/CHROMATIN ASSEMBLY FACTOR GROUP D 02 antikoerper, NUCLEOSOME/CHROMATIN ASSEMBLY FACTOR GROUP D 2 antikoerper, high mobility group B2 antikoerper, hmgb2 antikoerper, hmgb2l antikoerper, im:6909096 antikoerper, wu:fa20b02 antikoerper, zgc:101854 antikoerper, wu:fb22b10 antikoerper, wu:fc95d12 antikoerper, zgc:123215 antikoerper, high mobility group box 2 antikoerper, high mobility group box 2 S homeolog antikoerper, high mobility group B2 antikoerper, high mobility group box 2b antikoerper, high mobility group box 2a antikoerper, HMGB2 antikoerper, Hmgb2 antikoerper, hmgb2.S antikoerper, hmgb2b antikoerper, hmgb2a antikoerper
- Hintergrund
- Synonyms:HMG2 Background:Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. In the nucleus is an abundant chromatin-associated non-histone protein involved in transcription, chromatin remodeling and V(D)J recombination and probably other processes. Binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters by enhancing transcription factor binding and/or bringing distant regulatory sequences into close proximity(PubMed:7797075, PubMed:11909973, PubMed:19522541, PubMed:18413230, PubMed:19965638, PubMed:20123072). Involved in V(D)J recombination by acting as a cofactor of the RAG complex: acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences(RSS)(By similarity). Proposed to be involved in the innate immune response to nucleic acids by acting as a promiscuous immunogenic DNA/RNA sensor which cooperates with subsequent discriminative sensing by specific pattern recognition receptors(By similarity). In the extracellular compartment acts as a chemokine. Promotes proliferation and migration of endothelial cells implicating AGER/RAGE(PubMed:19811285). Has antimicrobial activity in gastrointestinal epithelial tissues(PubMed:23877675). Involved in inflammatory response to antigenic stimulus coupled with proinflammatory activity(By similarity). Involved in modulation of neurogenesis probably by regulation of neural stem proliferation(By similarity). Involved in articular cartilage surface maintenance implicating LEF1 and the Wnt/beta-catenin pathway(By similarity).
- Molekulargewicht
- 33-35 kDa
- Gen-ID
- 3148
- UniProt
- P26583
- Pathways
- Cellular Response to Molecule of Bacterial Origin
-