HMGB2 Antikörper (Internal Region)

Produktnummer ABIN6258843

Produktdetails anti-HMGB2 Antikörper

Target: HMGB2 (High Mobility Group Box 2 (HMGB2))

Bindungsspezifität: Internal Region

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HMGB2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Spezifität: HMGB2 Antibody detects endogenous levels of total HMGB2.

Homologie: Bovine,Horse,Sheep,Rabbit,Dog,Chicken

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human HMGB2, corresponding to a region within the internal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:1000, IF/ICC 1:100-1:500, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu HMGB2

Target: HMGB2 (High Mobility Group Box 2 (HMGB2))

Andere Bezeichnung: HMGB2 (HMGB2 Produkte)

Synonyme: HMG2 antikoerper, C80539 antikoerper, HMG-2 antikoerper, Hmg2 antikoerper, HIGH MOBILITY GROUP BETA 1 antikoerper, HMG BETA 1 antikoerper, NFD02 antikoerper, NFD2 antikoerper, NUCLEOSOME/CHROMATIN ASSEMBLY FACTOR GROUP D 02 antikoerper, NUCLEOSOME/CHROMATIN ASSEMBLY FACTOR GROUP D 2 antikoerper, high mobility group B2 antikoerper, hmgb2 antikoerper, hmgb2l antikoerper, im:6909096 antikoerper, wu:fa20b02 antikoerper, zgc:101854 antikoerper, wu:fb22b10 antikoerper, wu:fc95d12 antikoerper, zgc:123215 antikoerper, high mobility group box 2 antikoerper, high mobility group box 2 S homeolog antikoerper, high mobility group B2 antikoerper, high mobility group box 2b antikoerper, high mobility group box 2a antikoerper, HMGB2 antikoerper, Hmgb2 antikoerper, hmgb2.S antikoerper, hmgb2b antikoerper, hmgb2a antikoerper

Hintergrund:

Description: Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. In the nucleus is an abundant chromatin-associated non-histone protein involved in transcription, chromatin remodeling and V(D)J recombination and probably other processes. Binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters by enhancing transcription factor binding and/or bringing distant regulatory sequences into close proximity (PubMed:7797075, PubMed:11909973, PubMed:19522541, PubMed:18413230, PubMed:19965638, PubMed:20123072). Involved in V(D)J recombination by acting as a cofactor of the RAG complex: acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS) (By similarity). Proposed to be involved in the innate immune response to nucleic acids by acting as a promiscuous immunogenic DNA/RNA sensor which cooperates with subsequent discriminative sensing by specific pattern recognition receptors (By similarity). In the extracellular compartment acts as a chemokine. Promotes proliferation and migration of endothelial cells implicating AGER/RAGE (PubMed:19811285). Has antimicrobial activity in gastrointestinal epithelial tissues (PubMed:23877675). Involved in inflammatory response to antigenic stimulus coupled with proinflammatory activity (By similarity). Involved in modulation of neurogenesis probably by regulation of neural stem proliferation (By similarity). Involved in articular cartilage surface maintenance implicating LEF1 and the Wnt/beta-catenin pathway (By similarity).

Gene: HMGB2

Molekulargewicht: 27 kDa

Gen-ID: 3148

UniProt: P26583

Pathways: Cellular Response to Molecule of Bacterial Origin