PERK Antikörper
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- Target Alle PERK (EIF2AK3) Antikörper anzeigen
- PERK (EIF2AK3) (Eukaryotic Translation Initiation Factor 2-alpha Kinase 3 (EIF2AK3))
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser PERK Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- Immunogen
- eukaryotic translation initiation factor 2-alpha kinase 3
- Isotyp
- IgG
- Top Product
- Discover our top product EIF2AK3 Primärantikörper
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- Applikationshinweise
- Optimal working dilution should be determined by the investigator.
- Kommentare
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Y79 cells were subjected to SDS PAGE followed by western blot with FNab02692(ELOVL4 antibody) at dilution of 1:500
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Buffer
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freeze / thaw cycles.
- Lagerung
- -20 °C
- Haltbarkeit
- 12 months
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- Target
- PERK (EIF2AK3) (Eukaryotic Translation Initiation Factor 2-alpha Kinase 3 (EIF2AK3))
- Andere Bezeichnung
- EIF2AK3 (EIF2AK3 Produkte)
- Synonyme
- EIF2AK3 antikoerper, AI427929 antikoerper, Pek antikoerper, Perk antikoerper, PEK antikoerper, PERK antikoerper, WRS antikoerper, eukaryotic translation initiation factor 2 alpha kinase 3 antikoerper, EIF2AK3 antikoerper, Eif2ak3 antikoerper
- Hintergrund
- Synonyms:PEK, PERK Background:Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2(eIF-2-alpha/EIF2S1) on 'Ser-52' during the unfolded protein response(UPR) and in response to low amino acid availability. Converts phosphorylated eIF-2-alpha/EIF2S1 either in a global protein synthesis inhibitor, leading to a reduced overall utilization of amino acids, or to a translation initiation activator of specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion. Serves as a critical effector of unfolded protein response(UPR)-induced G1 growth arrest due to the loss of cyclin-D1(CCND1). Involved in control of mitochondrial morphology and function.
- Gen-ID
- 9451
- UniProt
- Q9NZJ5
- Pathways
- Hormone Transport, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Hepatitis C, Unfolded Protein Response
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