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BBS5 Antikörper

BBS5 Reaktivität: Human WB, ELISA Wirt: Maus Monoclonal unconjugated
Produktnummer ABIN5701809
  • Target Alle BBS5 Antikörper anzeigen
    BBS5 (Bardet-Biedl Syndrome 5 (BBS5))
    Reaktivität
    • 15
    • 7
    • 7
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Human
    Wirt
    • 12
    • 3
    Maus
    Klonalität
    • 14
    • 1
    Monoklonal
    Konjugat
    • 12
    • 1
    • 1
    • 1
    Dieser BBS5 Antikörper ist unkonjugiert
    Applikation
    • 11
    • 5
    • 4
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA
    Immunogen
    Bardet-Biedl syndrome 5
    Isotyp
    IgG2a
    Top Product
    Discover our top product BBS5 Primärantikörper
  • Applikationshinweise
    Optimal working dilution should be determined by the investigator.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freeze / thaw cycles.
    Lagerung
    -20 °C
    Haltbarkeit
    12 months
  • Target
    BBS5 (Bardet-Biedl Syndrome 5 (BBS5))
    Andere Bezeichnung
    BBS5 (BBS5 Produkte)
    Synonyme
    zgc:56578 antikoerper, 1700049I01Rik antikoerper, 2700023J09Rik antikoerper, Bardet-Biedl syndrome 5 antikoerper, Bardet-Biedl syndrome 5 (human) antikoerper, bbs5 antikoerper, BBS5 antikoerper, Bbs5 antikoerper
    Hintergrund
    Synonyms: Background:The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor(GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog(SHH) pathway regulation. Required for BBSome complex ciliary localization but not for the proper complex assembly.
    Molekulargewicht
    40-45 kDa
    Gen-ID
    129880
    UniProt
    Q8N3I7
    Pathways
    Hedgehog Signalweg
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