BBS5 Antikörper (C-Term)

Produktnummer ABIN6260212

Produktdetails anti-BBS5 Antikörper

Target: BBS5 (Bardet-Biedl Syndrome 5 (BBS5))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BBS5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Spezifität: BBS5 Antibody detects endogenous levels of total BBS5.

Homologie: Pig,Zebrafish,Bovine,Horse,Sheep,Chicken

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human BBS5, corresponding to a region within C-terminal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, IHC 1:50-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu BBS5

Target: BBS5 (Bardet-Biedl Syndrome 5 (BBS5))

Andere Bezeichnung: BBS5 (BBS5 Produkte)

Synonyme: zgc:56578 antikoerper, 1700049I01Rik antikoerper, 2700023J09Rik antikoerper, Bardet-Biedl syndrome 5 antikoerper, Bardet-Biedl syndrome 5 (human) antikoerper, bbs5 antikoerper, BBS5 antikoerper, Bbs5 antikoerper

Hintergrund:

Description: The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for BBSome complex ciliary localization but not for the proper complex assembly.

Gene: BBS5

Molekulargewicht: 40-45 kDa

Gen-ID: 129880

UniProt: Q8N3I7

Pathways: Hedgehog Signalweg