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DDB2 Antikörper

DDB2 Reaktivität: Human, Maus, Ratte WB, ELISA, IF Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN5700745
  • Target Alle DDB2 Antikörper anzeigen
    DDB2 (Damage-Specific DNA Binding Protein 2, 48kDa (DDB2))
    Reaktivität
    • 37
    • 17
    • 13
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 37
    • 2
    Kaninchen
    Klonalität
    • 27
    • 12
    Polyklonal
    Konjugat
    • 21
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Dieser DDB2 Antikörper ist unkonjugiert
    Applikation
    • 21
    • 9
    • 6
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (IF)
    Immunogen
    damage-specific DNA binding protein 2, 48kDa
    Isotyp
    IgG
    Top Product
    Discover our top product DDB2 Primärantikörper
  • Applikationshinweise
    Optimal working dilution should be determined by the investigator.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freeze / thaw cycles.
    Lagerung
    -20 °C
    Haltbarkeit
    12 months
  • Target
    DDB2 (Damage-Specific DNA Binding Protein 2, 48kDa (DDB2))
    Andere Bezeichnung
    DDB2 (DDB2 Produkte)
    Synonyme
    2610043A19Rik antikoerper, si:dkey-45f10.3 antikoerper, DDBB antikoerper, UV-DDB2 antikoerper, damage specific DNA binding protein 2 antikoerper, damage-specific DNA binding protein 2 antikoerper, DDB2 antikoerper, ddb2 antikoerper, Ddb2 antikoerper
    Hintergrund
    Synonyms: Background:Required for DNA repair. Binds to DDB1 to form the UV-damaged DNA-binding protein complex(the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway(the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers(CPD), 6-4 photoproducts(6-4 PP), apurinic sites and short mismatches. Also appears to function as the substrate recognition module for the DCX(DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex DDB1-CUL4-ROC1(also known as CUL4-DDB-ROC1 and CUL4-DDB-RBX1). The DDB1-CUL4-ROC1 complex may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage. The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair. The DDB1-CUL4-ROC1 complex also ubiquitinates XPC, which may enhance DNA-binding by XPC and promote NER. Isoform D1 and isoform D2 inhibit UV-damaged DNA repair.
    Molekulargewicht
    55-60 kDa
    Gen-ID
    1643
    UniProt
    Q92466
    Pathways
    DNA Reparatur
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