ABL2 Antikörper

Produktnummer ABIN5699120

Produktdetails anti-ABL2 Antikörper

Target: ABL2

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ABL2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

Immunogen: v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB :1:500-1:5000,IHC:1:20-1:200,IF:1:10-1:100,IP:1:200-1:2000

Kommentare:

HeLa cells were subjected to SDS PAGE followed by western blot with FNab00053(ABL2 antibody) at dilution of 1:500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Haltbarkeit: 12 months

Details zu ABL2

Target: ABL2

Andere Bezeichnung: ABL2 (ABL2 Produkte)

Synonyme: ABLL antikoerper, ARG antikoerper, Abll antikoerper, Arg antikoerper, AA536808 antikoerper, ABL proto-oncogene 2, non-receptor tyrosine kinase antikoerper, v-abl Abelson murine leukemia viral oncogene 2 (arg, Abelson-related gene) antikoerper, ABL2 antikoerper, Abl2 antikoerper

Hintergrund: Synonyms:Abelson related gene protein, ABL2, ABLL, ARG, FLJ22224, FLJ31718, FLJ41441, Tyrosine protein kinase ABL2, Tyrosine protein kinase ARG Background:Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10(involved in movement), CTTN(involved in signaling), or TUBA1 and TUBB(microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. ABL2 acts also as a regulator of multiple pathological signaling cascades during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1.

Molekulargewicht: 127kDa

Gen-ID: 27

UniProt: P42684