ABL2 Antikörper (AA 862-1064)

Produktnummer ABIN7174005

Produktdetails anti-ABL2 Antikörper

Target: ABL2

Bindungsspezifität: AA 862-1064

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ABL2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Tyrosine-protein kinase ABL2 protein (862-1064AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: WB:1:500-1:5000,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu ABL2

Target: ABL2

Andere Bezeichnung: ABL2 (ABL2 Produkte)

Synonyme: ABLL antikoerper, ARG antikoerper, Abll antikoerper, Arg antikoerper, AA536808 antikoerper, ABL proto-oncogene 2, non-receptor tyrosine kinase antikoerper, v-abl Abelson murine leukemia viral oncogene 2 (arg, Abelson-related gene) antikoerper, ABL2 antikoerper, Abl2 antikoerper

Hintergrund:

Background: Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement), CTTN (involved in signaling), or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. ABL2 acts also as a regulator of multiple pathological signaling cascades during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1.

Aliases: Abelson murine leukemia viral oncogene homolog 2 antibody, Abelson related gene protein antibody, Abelson tyrosine-protein kinase 2 antibody, Abelson-related gene protein antibody, ABL2 antibody, ABL2_HUMAN antibody, ABLL antibody, ARG antibody, Tyrosine kinase ARG antibody, Tyrosine protein kinase ABL2 antibody, Tyrosine-protein kinase ARG antibody, v abl Abelson murine leukemia viral oncogene homolog 2 antibody

UniProt: P42684