PD-1 Antikörper (AA 25-167)

Produktnummer ABIN5688354

Produktdetails anti-PD-1 Antikörper

Target: PD-1 (PDCD1) (Programmed Cell Death 1 (PDCD1))

Fragment: single-domain Antibody (sdAb)

Bindungsspezifität: AA 25-167

Reaktivität: Human

Wirt: Llama

Klonalität: Monoklonal

Konjugat: Dieser PD-1 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), ELISA

Aufreinigung: PD-1 Antibody is affinity chromatography purified via Nickel column.

Immunogen: PD-1 antibody was raised against a recombinant protein corresponding to amino acids 25 - 167 of human PD-1.

Klon: F1-2A8

Anwendungsinformationen

Applikationshinweise: PD-1 antibody can be used for detection of PD-1 by ELISA and FACS (10 μ,g/mL).

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PD-1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: PD-1 antibody should be stored in working aliquots at -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu PD-1

Target: PD-1 (PDCD1) (Programmed Cell Death 1 (PDCD1))

Andere Bezeichnung: PD-1 (PDCD1 Produkte)

Synonyme: CD279 antikoerper, PD-1 antikoerper, PD1 antikoerper, SLEB2 antikoerper, hPD-1 antikoerper, hPD-l antikoerper, Ly101 antikoerper, Pdc1 antikoerper, programmed cell death 1 antikoerper, PDCD1 antikoerper, Pdcd1 antikoerper

Hintergrund: PD-1 Antibody: Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antig en-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PDL-1 and PDL-2. Upon binding to either of these ligands, signals generated by PD-1 inhibit the activation of the immune response in the absence of "danger signals" such as LPS or other molecules associated with bacteria or other pathogens. Evidence for this is seen in PD1-null mice who exhibit hyperactivated immune systems and autoimmune diseases.

Gen-ID: 5133

NCBI Accession: NP_005009

UniProt: Q15116

Pathways: Cancer Immune Checkpoints