SMAD2 Antikörper

Produktnummer ABIN1513537

Produktdetails anti-SMAD2 Antikörper

Target: SMAD2 (SMAD, Mothers Against DPP Homolog 2 (SMAD2))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SMAD2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Aufreinigung: Affinity purification

Immunogen: Recombinant protein of human SMAD2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilutions: WB: 1:500-1:1000, IHC: 1:50-1:100, IF: 1:20-1:50

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid freeze / thaw cycles

Lagerung: -20 °C/-80 °C

Details zu SMAD2

Target: SMAD2 (SMAD, Mothers Against DPP Homolog 2 (SMAD2))

Andere Bezeichnung: SMAD2 (SMAD2 Produkte)

Synonyme: JV18 antikoerper, JV18-1 antikoerper, MADH2 antikoerper, MADR2 antikoerper, hMAD-2 antikoerper, hSMAD2 antikoerper, jv18 antikoerper, Xmad2 antikoerper, madh2 antikoerper, madr2 antikoerper, XSmad2 antikoerper, hmad-2 antikoerper, hsmad2 antikoerper, jv18-1 antikoerper, smad-2 antikoerper, fj43c06 antikoerper, wu:fj43c06 antikoerper, 7120426M23Rik antikoerper, Madh2 antikoerper, Madr2 antikoerper, Smad-2 antikoerper, mMad2 antikoerper, MAD homolog 2 antikoerper, Mothers against DPP homolog 2 antikoerper, SMAD 2 antikoerper, Smad2 antikoerper, SMAD family member 2 antikoerper, SMAD family member 2-Z antikoerper, SMAD family member 2 S homeolog antikoerper, SMAD2 antikoerper, SMAD2Z antikoerper, smad2 antikoerper, smad2.S antikoerper, Smad2 antikoerper

Hintergrund: Members of the Smad family of signal transduction molecules are components of a critical intracellular pathway that transmit TGF-beta signals from the cell surface into the nucleus. Three distinct classes of Smads have been defined: the receptor-regulated Smads (R-Smads), which include Smad1, 2, 3, 5, and 8, the common-mediator Smad (co-Smad), Smad4, and the antagonistic or inhibitory Smads (I-Smads), Smad6 and 7. Activated type I receptors associate with specific R-Smads and phosphorylate them on a conserved carboxy-terminal SSXS motif. The phosphorylated R-Smad dissociates from the receptor and forms a heteromeric complex with the co-Smad (Smad4), allowing translocation of the complex to the nucleus. Once in the nucleus, Smads can target a variety of DNA binding proteins to regulate transcriptional responses.
Synonyms: SMAD2, V18, JV18-1, MADH2, MADR2, MGC22139, MGC34440, hMAD-2, hSMAD2

Gen-ID: 4087

UniProt: Q15796

Pathways: Zellzyklus, Hormone Transport, Chromatin Binding, Protein targeting to Nucleus