COPS7B Antikörper (AA 223-257)

Produktnummer ABIN5647523

Produktdetails anti-COPS7B Antikörper

Target: COPS7B (COP9 Signalosome Complex Subunit 7b (COPS7B))

Bindungsspezifität: AA 223-257

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser COPS7B Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Kreuzreaktivität (Details): Expected species reactivity: Bovine

Aufreinigung: Antigen affinity purified

Immunogen: A portion of amino acids 223-257 from the human protein was used as the immunogen for the COPS7B antibody.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Western blot: 1:500-1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the COPS7B antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Details zu COPS7B

Target: COPS7B (COP9 Signalosome Complex Subunit 7b (COPS7B))

Andere Bezeichnung: COPS7B / CSN7b (COPS7B Produkte)

Synonyme: MGC114836 antikoerper, D1Wsu66e antikoerper, E130114M23 antikoerper, CSN7B antikoerper, COP9 signalosome subunit 7B antikoerper, COP9 signalosome subunit 7B S homeolog antikoerper, Cops7b antikoerper, COPS7B antikoerper, cops7b.S antikoerper

Hintergrund: COP9 signalosome complex subunit 7b is a component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.

Gen-ID: 64708

UniProt: Q9H9Q2

Pathways: Zellzyklus