ECT2 Antikörper (AA 200-460)

Produktnummer ABIN5647111

Produktdetails anti-ECT2 Antikörper

Target: ECT2 (Epithelial Cell Transforming Sequence 2 Oncogene (ECT2))

Bindungsspezifität: AA 200-460

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser ECT2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: Purified

Immunogen: A partial recombinant protein corresponding to amino acids 200-460 from the human protein was used as the immunogen for the ECT2 antibody.

Klon: 1691CT516-3-3

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: Western blot: 1:500-1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the ECT2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Details zu ECT2

Target: ECT2 (Epithelial Cell Transforming Sequence 2 Oncogene (ECT2))

Andere Bezeichnung: ECT2 (ECT2 Produkte)

Synonyme: ECT2 antikoerper, arhgef31 antikoerper, xect2 antikoerper, AI528536 antikoerper, mKIAA4037 antikoerper, ARHGEF31 antikoerper, ect2 antikoerper, epithelial cell transforming 2 antikoerper, ect2 oncogene antikoerper, epithelial cell transforming 2 S homeolog antikoerper, ECT2 antikoerper, ect2 antikoerper, Ect2 antikoerper, ect2.S antikoerper

Hintergrund: Epithelial cell-transforming sequence 2 oncogene is a guanine nucleotide exchange factor (GEF) that catalyzes the exchange of GDP for GTP. Promotes guanine nucleotide exchange on the Rho family members of small GTPases, like RHOA, RHOC, RAC1 and CDC42. Required for signal transduction pathways involved in the regulation of cytokinesis. Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Regulates the translocation of RHOA from the central spindle to the equatorial region. Plays a role in the control of mitotic spindle assembly, regulates the activation of CDC42 in metaphase for the process of spindle fibers attachment to kinetochores before chromosome congression. Involved in the regulation of epithelial cell polarity, participates in the formation of epithelial tight junctions in a polarity complex PARD3-PARD6-protein kinase PRKCQ-dependent manner. Plays a role in the regulation of neurite outgrowth. Inhibits phenobarbital (PB)- induced NR1I3 nuclear translocation. Stimulates the activity of RAC1 through its association with the oncogenic PARD6A-PRKCI complex in cancer cells, thereby acting to coordinately drive tumor cell proliferation and invasion. Also stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death.

Gen-ID: 1894

UniProt: Q9H8V3

Pathways: Neurotrophin Signalübertragung, Cell-Cell Junction Organization