TLR6 Antikörper (AA 280-512) (FITC)

Produktnummer ABIN5564273

Produktdetails anti-TLR6 Antikörper (FITC)

Target: TLR6 (Toll-Like Receptor 6 (TLR6))

Bindungsspezifität: AA 280-512

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser TLR6 Antikörper ist konjugiert mit FITC

Applikation: Flow Cytometry (FACS)

Spezifität: Recognizes human TLR6.

Kreuzreaktivität: Human

Aufreinigung: Protein G purified.

Immunogen: Recombinant human TLR6 protein (aa 280-512).

Klon: ABM1B50

Isotyp: IgG1

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: In 10 mM TRIS containing 150 mM NaCl and 0.05 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Short Term Storage: +4°C
Long Term Storage: +4°C
Stable for at least 6 months after receipt when stored at +4°C.

Haltbarkeit: 6 months

Details zu TLR6

Target: TLR6 (Toll-Like Receptor 6 (TLR6))

Andere Bezeichnung: TLR6 (TLR6 Produkte)

Synonyme: TLR1 antikoerper, TLR16 antikoerper, CD286 antikoerper, TLR-6 antikoerper, toll-like receptor 1 family member A antikoerper, toll like receptor 6 antikoerper, toll-like receptor 6 antikoerper, TLR1A antikoerper, TLR6 antikoerper, Tlr6 antikoerper

Hintergrund: TLR6 (Toll-like Receptor 6) is a member of the TLR (Toll-like receptor) family that plays a fundamental role in pathogen recognition and activation of innate immunity. TLR6 in complex with TLR2 specifically recognizes diacylated and, to a lesser extent, triacylated lipopeptides from Gram-positive bacteria and fungi. The activation cluster TLR2:TLR6:CD14:CD36 signals via MYD88 and TRAF6, leading to NF-kappaB activation, cytokine secretion and the inflammatory response. In complex with TLR2 recognizes MALP-2, STF, PSM and OspA-L, as well. In response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42, TLR6 forms a heterodimer with TLR4. This complex rapidly internalizes and triggers inflammatory responses through the NF-kappaB-dependent MYD88 signaling or via TICAM1 signaling pathways. The complex promotes sterile inflammation in monocytes/macrophages. TLR6 has emerged as the most potent activator for ZNPs (Zinc Oxide Nanoparticles)-induced inflammatory responses. Various polymorphism have been associated with inflammatory and tumor pathologies.

Pathways: TLR Signalweg, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades