TLR7 Antikörper (AA 500-900) (FITC)

Produktnummer ABIN5564263

Produktdetails anti-TLR7 Antikörper (FITC)

Target: TLR7 (Toll-Like Receptor 7 (TLR7))

Bindungsspezifität: AA 500-900

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser TLR7 Antikörper ist konjugiert mit FITC

Applikation: Flow Cytometry (FACS)

Spezifität: Recognizes human TLR7.

Kreuzreaktivität: Human

Aufreinigung: Protein G purified.

Immunogen: Recombinant human TLR7 protein (aa 500-900).

Klon: ABM2C27

Isotyp: IgG1

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: In 10 mM TRIS containing 150 mM NaCl and 0.05 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Short Term Storage: +4°C
Long Term Storage: +4°C
Stable for at least 6 months after receipt when stored at +4°C.

Haltbarkeit: 6 months

Details zu TLR7

Target: TLR7 (Toll-Like Receptor 7 (TLR7))

Andere Bezeichnung: TLR7 (TLR7 Produkte)

Synonyme: TLR7-like antikoerper, RGD1563357 antikoerper, toll like receptor 7 antikoerper, toll-like receptor 7 antikoerper, TLR7 antikoerper, Tlr7 antikoerper

Hintergrund: TLR7 (Toll-like Receptor 7) is a member of the TLR (Toll-like receptor) family that plays a fundamental role in pathogen recognition and activation of innate immunity. TLR7 is a nucleotide-sensing TLR. TLR7 and TLR8 recognize single-stranded RNA (ssRNA) sequences containing GU-rich or poly-U sequences as their natural ligands, and they are also activated by synthetic small-molecular-weight compounds of the imidazoquinoline family. Both TLR7 and TLR8 signal via MYD88 and TRAF6, leading to NF-kappaB and antiviral factor, such as IRF family activation, cytokine secretion and the inflammatory response. They are localized intracellularly to endosomal membranes and act as potent activators of innate immune responses upon viral infection. The TLR7 gene is predominantly expressed in lung, placenta and spleen, and lies in close proximity to TLR8 on chromosome X. TLR7 has been shown to play a significant role in the pathogenesis of autoimmune disorders such as Systemic Lupus Erythematosus (SLE) as well as in the regulation of antiviral immunity. Recently, small molecule TLR7/8 agonists have demonstrated potential as vaccine adjuvants, since they directly activate APCs and can enhance both humoral and cellular immune responses, especially Th1 responses. This makes the TLR7/8 signaling pathways interesting therapeutic targets.

Pathways: TLR Signalweg, Activation of Innate immune Response, Toll-Like Receptors Cascades