XAF1 Antikörper (XiAP Associated Factor 1) (C-Term)

Details for Product anti-XAF1 Antibody No. ABIN5555418, Anbieter: Anmelden zum Anzeigen
Antigen
  • BIRC4BP
  • HSXIAPAF1
  • XIAPAF1
  • Fbxo39
  • XIAP associated factor 1
  • xaf1
  • XAF1
  • Xaf1
Epitop
C-Term
21
17
9
9
8
4
3
3
2
2
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human, Maus
73
39
9
2
Wirt
Kaninchen
85
6
Klonalität
Polyklonal
Konjugat
Dieser XAF1 Antikörper ist unkonjugiert
2
2
2
2
2
2
2
1
Applikation
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
87
31
25
19
11
6
5
1
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Immunogen XAF-1 antibody was raised against a synthetic peptide corresponding to amino acids at the C-terminus of human XAF-1.
Isotyp IgG
Spezifität This antibody detects XAF-1.
Kreuzreaktivität (Details) Species reactivity (tested):Human, mouse
Reinigung Affinity chromatography
Andere Bezeichnung XAF1 (XAF1 Antibody Abstract)
Hintergrund XAF-1 binds to XIAP, an inhibitor of caspases-3, -7, and -9, and triggers its relocation from the cytosol to the nucleus (1,2). Overexpression of XAF-1 results in the neutralization of XIAP\'s ability to inhibit cell death (1). XAF-1 is normally expressed in all adult and fetal tissues but was found to be present in very low levels in a variety of cancer cell lines (3). In contrast, XIAP levels have been shown to be high in a majority of cell lines. Low XAF-1 and high basal expression of XIAP may therefore play a critical role in maintaining survival of cancer cell lines (2,3). Both IFN-alpha2 and IFN-beta can induce XAF-1 mRNA in all cells examined but induction of XAF-1 protein (as observed by immunoblot analysis) was seen only in cell lines sensitive to the apoptotic effects of IFNs (4).Synonyms: BIRC4-binding protein, BIRC4BP, XIAP-associated factor 1, XIAPAF1
Gen-ID 54739
NCBI Accession NP_059993
Applikationshinweise ELISA. Immunohistochemistry on paraffin sections. Western blot.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Beschränkungen Nur für Forschungszwecke einsetzbar
Buffer PBS containing 0.02 % sodium azide
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Avoid repeated freezing and thawing.
Lagerung 4 °C/-20 °C
Informationen zur Lagerung Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
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