PKD2 Antikörper (C-Term)

Produktnummer ABIN5537773

Produktdetails anti-PKD2 Antikörper

Target: PKD2 (Polycystic Kidney Disease 2 (Autosomal Dominant) (PKD2))

Bindungsspezifität: AA 937-968, C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PKD2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Immunogen: This PKD2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 937-968 amino acids from the C-terminal region of human PKD2.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: For IHC-P starting dilution is: 1:50~100

For WB starting dilution is: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1.9 mg/mL

Buffer: Supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu PKD2

Target: PKD2 (Polycystic Kidney Disease 2 (Autosomal Dominant) (PKD2))

Andere Bezeichnung: PKD2 (PKD2 Produkte)

Synonyme: APKD2 antikoerper, PC2 antikoerper, PKD4 antikoerper, Pc-2 antikoerper, TRPP2 antikoerper, C030034P18Rik antikoerper, RGD1559992 antikoerper, pkd2 antikoerper, trpp2 antikoerper, Cup antikoerper, PKD2L1 antikoerper, polycystin 2, transient receptor potential cation channel antikoerper, polycystic kidney disease 2 antikoerper, Polycystin-2 antikoerper, polycystin 2, transient receptor potential cation channel L homeolog antikoerper, PKD2 antikoerper, Pkd2 antikoerper, pkd-2 antikoerper, pkd2.L antikoerper, pkd2 antikoerper

Hintergrund: Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium. PKD1 and PKD2 may function through a common signaling pathway that is necessary for normal tubulogenesis. Acts as a regulator of cilium length, together with PKD1. The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling. Functions as a calcium permeable cation channel.

Molekulargewicht: 110 kDa

Gen-ID: 5311

UniProt: Q13563

Pathways: cAMP Metabolic Process, Maintenance of Protein Location, Negative Regulation of Transporter Activity