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PKD2 Antikörper (C-Term)

PKD2 Reaktivität: Human ELISA, WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6264257
  • Target Alle PKD2 Antikörper anzeigen
    PKD2 (Polycystic Kidney Disease 2 (Autosomal Dominant) (PKD2))
    Bindungsspezifität
    • 15
    • 12
    • 10
    • 8
    • 7
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reaktivität
    • 62
    • 53
    • 19
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 69
    • 3
    • 1
    Kaninchen
    Klonalität
    • 71
    • 3
    Polyklonal
    Konjugat
    • 37
    • 6
    • 5
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser PKD2 Antikörper ist unkonjugiert
    Applikation
    • 40
    • 39
    • 13
    • 13
    • 9
    • 8
    • 7
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    ELISA, Western Blotting (WB)
    Spezifität
    PKD2 Antibody detects endogenous levels of total PKD2.
    Homologie
    Zebrafish,Horse,Rabbit,Dog,Chicken,Xenopus
    Aufreinigung
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human PKD2, corresponding to a region within C-terminal amino acids.
    Isotyp
    IgG
    Top Product
    Discover our top product PKD2 Primärantikörper
  • Applikationshinweise
    WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20 °C. Stable for 12 months from date of receipt.
    Haltbarkeit
    12 months
  • Target
    PKD2 (Polycystic Kidney Disease 2 (Autosomal Dominant) (PKD2))
    Andere Bezeichnung
    PKD2 (PKD2 Produkte)
    Synonyme
    APKD2 antikoerper, PC2 antikoerper, PKD4 antikoerper, Pc-2 antikoerper, TRPP2 antikoerper, C030034P18Rik antikoerper, RGD1559992 antikoerper, pkd2 antikoerper, trpp2 antikoerper, Cup antikoerper, PKD2L1 antikoerper, polycystin 2, transient receptor potential cation channel antikoerper, polycystic kidney disease 2 antikoerper, Polycystin-2 antikoerper, polycystin 2, transient receptor potential cation channel L homeolog antikoerper, PKD2 antikoerper, Pkd2 antikoerper, pkd-2 antikoerper, pkd2.L antikoerper, pkd2 antikoerper
    Hintergrund

    Description: Functions as a cation channel involved in fluid-flow mechanosensation by the primary cilium in renal epithelium (PubMed:18695040). Functions as outward-rectifying K+ channel, but is also permeable to Ca2+, and to a much lesser degree also to Na+ (PubMed:11854751, PubMed:15692563, PubMed:27071085, PubMed:27991905). May contribute to the release of Ca2+ stores from the endoplasmic reticulum (PubMed:11854751, PubMed:20881056). Together with TRPV4, forms mechano- and thermosensitive channels in cilium (PubMed:18695040). PKD1 and PKD2 may function through a common signaling pathway that is necessary to maintain the normal, differentiated state of renal tubule cells. Acts as a regulator of cilium length, together with PKD1. The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling. Also involved in left-right axis specification via its role in sensing nodal flow, forms a complex with PKD1L1 in cilia to facilitate flow detection in left-right patterning. Detection of asymmetric nodal flow gives rise to a Ca2+ signal that is required for normal, asymmetric expression of genes involved in the specification of body left-right laterality (By similarity).

    Gene: PKD2

    Molekulargewicht
    96kDa
    Gen-ID
    5311
    UniProt
    Q13563
    Pathways
    cAMP Metabolic Process, Maintenance of Protein Location, Negative Regulation of Transporter Activity
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