PTTG1 Antikörper (N-Term)

Produktnummer ABIN5534624

Produktdetails anti-PTTG1 Antikörper

Target: PTTG1 (Pituitary Tumor-Transforming 1 (PTTG1))

Bindungsspezifität: AA 16-45, N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PTTG1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Immunogen: This PTTG1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 16-45 amino acids from the N-terminal region of human PTTG1.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: For WB starting dilution is: 1:500

For IF starting dilution is: 1:100

For IHC-P starting dilution is: 1:50~100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 2 mg/mL

Buffer: Supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu PTTG1

Target: PTTG1 (Pituitary Tumor-Transforming 1 (PTTG1))

Andere Bezeichnung: PTTG1 (PTTG1 Produkte)

Synonyme: EAP1 antikoerper, HPTTG antikoerper, PTTG antikoerper, TUTR1 antikoerper, PTTG1 antikoerper, securin antikoerper, AW555095 antikoerper, C87862 antikoerper, Pttg antikoerper, Pttg3 antikoerper, Securin antikoerper, Protein Cut2 antikoerper, pituitary tumor-transforming 1 antikoerper, pituitary tumor-transforming gene 1 antikoerper, securin, sister chromatid separation inhibitor antikoerper, PTTG1 antikoerper, Pttg1 antikoerper, cut2 antikoerper

Hintergrund: PTTG1 is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The protein has transforming activity in vitro and tumorigenic activity in vivo, and is highly expressed in various tumors. This protein contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the protein can act as a transactivation domain. It is mainly a cytosolic protein, although it partially localizes in the nucleus.

Molekulargewicht: 22 kDa

Gen-ID: 9232

UniProt: O95997