PTTG1 Antikörper

Produktnummer ABIN7264333

Produktdetails anti-PTTG1 Antikörper

Target: PTTG1 (Pituitary Tumor-Transforming 1 (PTTG1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PTTG1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktmerkmale: Polyclonal Antibody

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein of human PTTG1 (NP_001269311.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000 IHC 1:100-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu PTTG1

Target: PTTG1 (Pituitary Tumor-Transforming 1 (PTTG1))

Andere Bezeichnung: PTTG1 (PTTG1 Produkte)

Synonyme: EAP1 antikoerper, HPTTG antikoerper, PTTG antikoerper, TUTR1 antikoerper, PTTG1 antikoerper, securin antikoerper, AW555095 antikoerper, C87862 antikoerper, Pttg antikoerper, Pttg3 antikoerper, Securin antikoerper, Protein Cut2 antikoerper, pituitary tumor-transforming 1 antikoerper, pituitary tumor-transforming gene 1 antikoerper, securin, sister chromatid separation inhibitor antikoerper, PTTG1 antikoerper, Pttg1 antikoerper, cut2 antikoerper

Hintergrund: The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus. Three transcript variants encoding the same protein have been found for this gene.

Molekulargewicht:

Observed_MW: 24 kDa

Calculated_MW: 22 kDa

Gen-ID: 9232

UniProt: O95997