TIM3 Antikörper (N-Term)

Produktnummer ABIN5533556

Produktdetails anti-TIM3 Antikörper

Target: TIM3 (TIM 3) (Hepatitis A Virus Cellular Receptor 2 (TIM 3))

Bindungsspezifität: N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TIM3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Spezifität: At least two antibodies are known to exist, this antibody will detect both isoforms.

Aufreinigung: TIM3 Antibody is affinity chromatography purified via peptide column.

Immunogen: TIM3 antibody was raised against a peptide corresponding to 16 amino acids near the amino terminus of human TIM3.

The immunogen is located within amino acids 60 - 110 of TIM3.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: TIM3 antibody can be used for Western blot at 1 - 2 μ,g/mL.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: TIM3 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: TIM3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu TIM3

Target: TIM3 (TIM 3) (Hepatitis A Virus Cellular Receptor 2 (TIM 3))

Andere Bezeichnung: TIM3 (TIM 3 Produkte)

Synonyme: HAVCR2 antikoerper, MGC140131 antikoerper, HAVcr-2 antikoerper, KIM-3 antikoerper, TIM3 antikoerper, TIMD-3 antikoerper, TIMD3 antikoerper, Tim-3 antikoerper, TIM-3 antikoerper, Tim3 antikoerper, Timd3 antikoerper, tim3 antikoerper, hepatitis A virus cellular receptor 2 antikoerper, HAVCR2 antikoerper, Havcr2 antikoerper

Substanzklasse: Virus

Hintergrund: The immune checkpoint protein TIM3 is a member of the immunoglobulin superfamily and TIM family of proteins that was initially identified as a specific marker of fully differentiated IFN-γ producing CD4 T helper 1 (Th1) and CD8 cytotoxic cells. It is a Th1-specific cell surface protein that regulates macrophage activation and negatively regulates Th1-mediated auto- and alloimmune responses, and is also highly expressed on regulatory T cells, monocytes, macrophages, and dendritic cells (1). TIM3 and PD-1 are co-expressed on most CD4 and CD8 T cells infiltrating solid tumors or in hematologic malignancy in mice, blocking TIM3 in conjugation with a PD-1 blockade increases the functionality of exhausted T cells and synergizes with to inhibit tumor growth (2,3).

Molekulargewicht: Predicted: 33 kDa

Observed: 37 kDa

Gen-ID: 84868

NCBI Accession: NP_116171

UniProt: Q8TDQ0

Pathways: Regulation of Lipid Metabolism by PPARalpha, Cancer Immune Checkpoints