Cyclin E1 Antikörper (C-Term)
-
- Target Alle Cyclin E1 (CCNE1) Antikörper anzeigen
- Cyclin E1 (CCNE1)
-
Bindungsspezifität
- AA 373-402, C-Term
-
Reaktivität
- Human
-
Wirt
- Kaninchen
-
Klonalität
- Polyklonal
-
Konjugat
- Dieser Cyclin E1 Antikörper ist unkonjugiert
-
Applikation
- Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Aufreinigung
- This antibody is purified through a protein A column, followed by peptide affinity purification.
- Immunogen
- This CCNE1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 373-402 amino acids from the C-terminal region of human CCNE1.
- Isotyp
- Ig Fraction
- Top Product
- Discover our top product CCNE1 Primärantikörper
-
-
- Applikationshinweise
-
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:50~100
For FACS starting dilution is: 1:10~50 - Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
- Format
- Liquid
- Konzentration
- 0.45 mg/mL
- Buffer
- Supplied in PBS with 0.09 % (W/V) sodium azide.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C,-20 °C
- Informationen zur Lagerung
- Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
-
- Target
- Cyclin E1 (CCNE1)
- Andere Bezeichnung
- CCNE1 (CCNE1 Produkte)
- Synonyme
- CCNE1 antikoerper, ccne antikoerper, cyclinE antikoerper, CCNE antikoerper, AW538188 antikoerper, CycE1 antikoerper, CYCLE antikoerper, Ccne antikoerper, cyce2 antikoerper, cycE3 antikoerper, cyce antikoerper, fa18e07 antikoerper, wu:fa18e07 antikoerper, cyclin E1 antikoerper, cyclin E1 L homeolog antikoerper, cyclin E1 S homeolog antikoerper, CCNE1 antikoerper, ccne1 antikoerper, Ccne1 antikoerper, ccne1.L antikoerper, ccne1.S antikoerper
- Hintergrund
- Cyclin E1 belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. Cyclin E1 forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. Cyclin E1 accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of Cyclin E1 has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB.
- Molekulargewicht
- 47 kDa
- Gen-ID
- 898
- UniProt
- P24864
- Pathways
- Zellzyklus, Intracellular Steroid Hormone Receptor Signaling Pathway, Nuclear Hormone Receptor Binding, Mitotic G1-G1/S Phases
-