KDM5B Antikörper (C-Term)

Produktnummer ABIN5517137

Produktdetails anti-KDM5B Antikörper

Target: KDM5B (Lysine (K)-Specific Demethylase 5B (KDM5B))

Bindungsspezifität: C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KDM5B Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: EMKKFPDNDL LRHLRLVTQD AEKCASVAQQ LLNGKRQTRY RSGGGKSQNQ

Produktmerkmale: This is a rabbit polyclonal antibody against KDM5B. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human KDM5B

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu KDM5B

Target: KDM5B (Lysine (K)-Specific Demethylase 5B (KDM5B))

Andere Bezeichnung: KDM5B (KDM5B Produkte)

Synonyme: jarid1b antikoerper, jarid1ba antikoerper, id:ibd5050 antikoerper, wu:fd15c05 antikoerper, cb264 antikoerper, jarid1bb antikoerper, plu1 antikoerper, wu:fc44h11 antikoerper, zgc:85741 antikoerper, JARID1B antikoerper, CT31 antikoerper, PLU-1 antikoerper, PLU1 antikoerper, PUT1 antikoerper, RBBP2H1A antikoerper, 2010009J12Rik antikoerper, 2210016I17Rik antikoerper, AW556288 antikoerper, D1Ertd202e antikoerper, Jarid1b antikoerper, Plu1 antikoerper, Rb-Bp2 antikoerper, mKIAA4034 antikoerper, RGD1565602 antikoerper, lysine (K)-specific demethylase 5Ba antikoerper, lysine (K)-specific demethylase 5Bb antikoerper, lysine demethylase 5B antikoerper, lysine (K)-specific demethylase 5B antikoerper, kdm5ba antikoerper, kdm5bb antikoerper, KDM5B antikoerper, Kdm5b antikoerper

Hintergrund: KDM5B is a histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. It does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. KDM5B demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. It acts as a transcriptional corepressor for FOXG1B and PAX9. It favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, KDM5B may act as a tumor suppressor for melanoma.

Alias Symbols: KDM5B, JARID1B, PLU1, RBBP2H1,

Protein Interaction Partner: FBXW11, UBC, HDAC2, HDAC4, SUMO1, SUMO3, PPP1CA, TFAP2C, MYC, HDAC7, HDAC5, NCOR1, PAX9, HDAC1, ELAVL1, CHD3, MTA3, MBD3, KDM1A, MTA2, MBD2, RBBP7, RBBP4, RB1, SUMO2, KLF10, LMO2, FOXG1, AR, VGLL3, PRDM13, ARID1B, BMP2K, RNF43, RBM15B, DBNL, CECR6, SLC39A

Protein Size: 1544

Gen-ID: 10765

NCBI Accession: NP_006609

UniProt: Q9UGL1

Pathways: Warburg Effekt