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FZR1 Antikörper (N-Term)
FZR1
Reaktivität: Human
WB
Wirt: Kaninchen
Polyclonal
unconjugated
Produktnummer ABIN5516022
Produktdetails anti-FZR1 Antikörper
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Target
Alle FZR1 Antikörper anzeigen
FZR1
(Fizzy/cell Division Cycle 20 Related 1 (FZR1))
Bindungsspezifität
Alle Epitope für FZR1 Antikörper
N-Term
Reaktivität
Alle Reaktivitäten für FZR1 Antikörper
Human
Wirt
Alle Wirte für FZR1 Antikörper
Kaninchen
Klonalität
Alle Klonalitäten für FZR1 Antikörper
Polyklonal
Konjugat
Alle Konjugate für FZR1 Antikörper
Dieser FZR1 Antikörper ist unkonjugiert
Applikation
Alle Applikationen für FZR1 Antikörper
Western Blotting (WB)
Sequenz
SKHGDRFIPS RAGANWSVNF HRINENEKSP SQNRKAKDAT SDNGKDGLAY
Produktmerkmale
This is a rabbit polyclonal antibody against FZR. It was validated on Western Blot.
Aufreinigung
Affinity Purified
Immunogen
The immunogen is a synthetic peptide directed towards the N-terminal region of Human FZR
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Discover our top product FZR1 Primärantikörper
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Anwendungsinformationen
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Applikationshinweise
Optimal working dilution should be determined by the investigator.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Handhabung
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Format
Liquid
Buffer
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
-20 °C
Informationen zur Lagerung
For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Details zu FZR1
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Target
FZR1
(Fizzy/cell Division Cycle 20 Related 1 (FZR1))
Andere Bezeichnung
FZR (FZR1 Produkte )
Synonyme
CDH1-C antikoerper, FYR antikoerper, FZR antikoerper, CDH1 antikoerper, fzr1 antikoerper, CDC20C antikoerper, FZR2 antikoerper, HCDH antikoerper, HCDH1 antikoerper, AW108046 antikoerper, Cdh1 antikoerper, Fyr antikoerper, zgc:55450 antikoerper, fizzy and cell division cycle 20 related 1 antikoerper, fizzy/cell division cycle 20 related 1 antikoerper, fizzy-related protein homolog antikoerper, fizzy/cell division cycle 20 related 1 (Drosophila) antikoerper, fizzy/cell division cycle 20 related 1a antikoerper, Fzr1 antikoerper, CDH1-C antikoerper, FZR1 antikoerper, LOC100027495 antikoerper, LOC100179951 antikoerper, fzr1a antikoerper
Hintergrund
FZR is a key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis. Alias Symbols: FZR1, CDH1, FYR, FZR, KIAA1242, Protein Interaction Partner: ZC3HC1, CDC25A, CCNB1, UBE2S, UBE2C, PTTG1, UBE2D2, TP53, CDR2, UBE2K, ANAPC4, PDS1, STAU1, CDK2, CDC27, RACGAP1, FOXM1, HECW2, PHF8, BTRC, CCNA1, UBC, SOX2, SKP2, PLK1, CUL1, CUEDC2, CDC20, kif22, SIRT2, CLSPN, ANAPC11, CDC14B, VHL, PTEN, EYA1, DAXX, BUB Protein Size: 496
Gen-ID
51343
NCBI Accession
XP_005259630
UniProt
Q9UM11
Pathways
DNA Replication , Synthesis of DNA
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