FZR1 Antikörper (AA 1-496)

Produktnummer ABIN6243204

Produktdetails anti-FZR1 Antikörper

Target: FZR1 (Fizzy/cell Division Cycle 20 Related 1 (FZR1))

Bindungsspezifität: AA 1-496

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser FZR1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: This antibody is purified through a protein G column, followed by dialysis against PBS.

Immunogen: This FZR antibody is generated from a mouse immunized with a recombinant protein between1-496 amino acids from human FZR.

Klon: 1621CT637-76-67

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: WB: 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Details zu FZR1

Target: FZR1 (Fizzy/cell Division Cycle 20 Related 1 (FZR1))

Andere Bezeichnung: FZR (FZR1 Produkte)

Synonyme: CDH1-C antikoerper, FYR antikoerper, FZR antikoerper, CDH1 antikoerper, fzr1 antikoerper, CDC20C antikoerper, FZR2 antikoerper, HCDH antikoerper, HCDH1 antikoerper, AW108046 antikoerper, Cdh1 antikoerper, Fyr antikoerper, zgc:55450 antikoerper, fizzy and cell division cycle 20 related 1 antikoerper, fizzy/cell division cycle 20 related 1 antikoerper, fizzy-related protein homolog antikoerper, fizzy/cell division cycle 20 related 1 (Drosophila) antikoerper, fizzy/cell division cycle 20 related 1a antikoerper, Fzr1 antikoerper, CDH1-C antikoerper, FZR1 antikoerper, LOC100027495 antikoerper, LOC100179951 antikoerper, fzr1a antikoerper

Hintergrund: Key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis.

Molekulargewicht: 55179

UniProt: Q9UM11

Pathways: DNA Replication, Synthesis of DNA