OAZ1 Antikörper (Middle Region)

Produktnummer ABIN5515002

Produktdetails anti-OAZ1 Antikörper

Target: OAZ1 (Ornithine Decarboxylase Antizyme 1 (OAZ1))

Bindungsspezifität: Middle Region

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser OAZ1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: PHPPLKIPGG RGNSQRDHSL SASILYSDER LNVTEEPTSN DKTRVLSIQS

Aufreinigung: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of rat OAZ1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 16 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu OAZ1

Target: OAZ1 (Ornithine Decarboxylase Antizyme 1 (OAZ1))

Andere Bezeichnung: OAZ1 (OAZ1 Produkte)

Synonyme: AZI antikoerper, OAZ antikoerper, AZ-1 antikoerper, AZ1 antikoerper, Antizyme antikoerper, ODC-Az antikoerper, Oaz antikoerper, ODCAC antikoerper, oaz antikoerper, AZS antikoerper, oaz1 antikoerper, ornithine decarboxylase antizyme 1 antikoerper, ornithine decarboxylase antizyme 1 S homeolog antikoerper, ornithine decarboxylase antizyme 1a antikoerper, OAZ1 antikoerper, Oaz1 antikoerper, oaz1.S antikoerper, oaz1a antikoerper

Hintergrund: The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis, thus, completing the auto-regulatory circuit. This gene encodes antizyme 1, the first member of the antizyme family, that has broad tissue distribution, and negatively regulates intracellular polyamine levels by binding to and targeting ODC for degradation, as well as inhibiting polyamine uptake. Antizyme 1 mRNA contains two potential in-frame AUGs, and studies in rat suggest that alternative use of the two translation initiation sites results in N-terminally distinct protein isoforms with different subcellular localization. Alternatively spliced transcript variants have also been noted for this gene.

Alias Symbols: AZ1, Oaz, AZ-1, ODC-Az, Antizyme,

Protein Size: 227

Gen-ID: 18245

NCBI Accession: NM_008753, NP_032779

UniProt: P54369