OAZ1 Antikörper (AA 14-63)

Produktnummer ABIN1535135

Der Kaninchen Polyklonal anti-OAZ1 Antikörper (ABIN1535135) detektiert spezifisch OAZ1 in IHC, WB, ELISA und IF. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus und Ratte.

Kurzübersicht für OAZ1 Antikörper (AA 14-63) (ABIN1535135)

Target: OAZ1 (Ornithine Decarboxylase Antizyme 1 (OAZ1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser OAZ1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Western Blotting (WB), ELISA, Immunofluorescence (IF)

Produktdetails anti-OAZ1 Antikörper

Bindungsspezifität: AA 14-63

Verwendungszweck: AZ1 Antibody

Spezifität: AZ1 Polyclonal Antibody detects endogenous levels of AZ1 protein.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Reinheit: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human OAZ1. AA range:14-63

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC 1:100 - 1:300. ELISA: 1:40000,WB 1:500-2000. IF 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C/1 year

Haltbarkeit: 12 months

Details zu OAZ1

Target: OAZ1 (Ornithine Decarboxylase Antizyme 1 (OAZ1))

Andere Bezeichnung: OAZ1

Hintergrund:

Synonyms: OAZ1, OAZ, Ornithine decarboxylase antizyme 1, ODC-Az

Background: The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis, thus, completing the auto-regulatory circuit.This gene encodes antizyme 1, the first member of the antizyme family, that has broad tissue distribution, and negatively regulates intracellular polyamine levels by binding to and targeting ODC for degradation, as well as inhibiting polyamine uptake. Antizyme 1 mRNA contains two potential in-frame AUGs, and studies in rat suggest that alternative use of the two translation initiation sites results in N-terminally distinct protein isoforms

Gene Name: OAZ1

Protein Name: Ornithine decarboxylase antizyme 1

Molekulargewicht: 25 kDa

Gen-ID: 4946

OMIM: 601579

UniProt: P54368