PD-1 Antikörper (AA 21-167)

Produktnummer ABIN532977

Produktdetails anti-PD-1 Antikörper

Target: PD-1 (PDCD1) (Programmed Cell Death 1 (PDCD1))

Bindungsspezifität: AA 21-167

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser PD-1 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Verwendungszweck: Mouse monoclonal antibody raised against partial recombinant PDCD1.

Kreuzreaktivität: Human

Immunogen: Recombinant protein corresponding to amino acids 21-167 of human PDCD1.

Klon: 4F12

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise: Western Blot (1:500-1:1000)
The optimal working dilution should be determined by the end user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In PBS, pH 7.4 (10 % glycerol, 0.02 % sodium azide).

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Store at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20°C to -80°C.
Aliquot to avoid repeated freezing and thawing.

Referenzen für anti-PD-1 Antikörper (ABIN532977)

Latchman, Wood, Chernova, Chaudhary, Borde, Chernova, Iwai, Long, Brown, Nunes, Greenfield, Bourque, Boussiotis, Carter, Carreno, Malenkovich, Nishimura, Okazaki, Honjo, Sharpe, Freeman: "PD-L2 is a second ligand for PD-1 and inhibits T cell activation." in: Nature immunology, Vol. 2, Issue 3, pp. 261-8, (2001) (PubMed).

Nishimura, Honjo: "PD-1: an inhibitory immunoreceptor involved in peripheral tolerance." in: Trends in immunology, Vol. 22, Issue 5, pp. 265-8, (2001) (PubMed).

Okazaki, Maeda, Nishimura, Kurosaki, Honjo: "PD-1 immunoreceptor inhibits B cell receptor-mediated signaling by recruiting src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosine." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, Issue 24, pp. 13866-71, (2001) (PubMed).

Details zu PD-1

Target: PD-1 (PDCD1) (Programmed Cell Death 1 (PDCD1))

Andere Bezeichnung: CD279 / PD1 (PDCD1 Produkte)

Synonyme: CD279 antikoerper, PD-1 antikoerper, PD1 antikoerper, SLEB2 antikoerper, hPD-1 antikoerper, hPD-l antikoerper, Ly101 antikoerper, Pdc1 antikoerper, programmed cell death 1 antikoerper, PDCD1 antikoerper, Pdcd1 antikoerper

Gen-ID: 5133

Pathways: Cancer Immune Checkpoints