EGLN1 Antikörper (AA 1-50)

Produktnummer ABIN504713

Produktdetails anti-EGLN1 Antikörper

Target: EGLN1 (Egl-9 Family Hypoxia Inducible Factor 1 (EGLN1))

Bindungsspezifität: AA 1-50

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser EGLN1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Kreuzreaktivität: Rind (Kuh), Human, Ratte (Rattus)

Aufreinigung: Aff - Purified

Immunogen: A peptide within AA 1-50 of the human protein. [Swiss-Prot# Q9GZT9].

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Lagerung: -20 °C

Details zu EGLN1

Target: EGLN1 (Egl-9 Family Hypoxia Inducible Factor 1 (EGLN1))

Andere Bezeichnung: HIF Prolyl Hydroxylase 2 (EGLN1 Produkte)

Synonyme: EGLN1 antikoerper, egln2 antikoerper, phd2 antikoerper, zgc:92314 antikoerper, AI503754 antikoerper, C1orf12 antikoerper, HIF-PH2 antikoerper, HPH-2 antikoerper, Hif-p4h-2 antikoerper, ORF13 antikoerper, Phd2 antikoerper, SM-20 antikoerper, PHD-2 antikoerper, PHD2 antikoerper, ECYT3 antikoerper, HIFPH2 antikoerper, HPH2 antikoerper, SM20 antikoerper, ZMYND6 antikoerper, egl nine homolog 1 (C. elegans) antikoerper, egl-9 family hypoxia inducible factor 1 antikoerper, egl-9 family hypoxia-inducible factor 1 S homeolog antikoerper, egl-9 family hypoxia-inducible factor 1b antikoerper, egl-9 family hypoxia-inducible factor 1 antikoerper, EGLN1 antikoerper, egln1.S antikoerper, egln1b antikoerper, Egln1 antikoerper

Hintergrund: HIF prolyl hydroxylase 2 is a prolyl hydroxylase that modifies HIF-alpha. Classic prolyl hydroxylases are found in the endoplasmic reticulum and modify collagen, whereas HIF is an intracellular protein and the HPH sites do not resemble those modifying collagen. HIF is a transcriptional complex that plays a critical role in oxygen homeostasis. HPH is an essential component of the pathway through which cells sense oxygen. In the presence of oxygen, HPHs convert specific prolyl residues in HIF-alpha to hydroxyproline, leading to HIF-alpha destruction. Low oxygen levels, sensed at the cellular level, cause the HIF conversion to be reduced so that HIF is stable and there is increased angiogenesis. HPH-2, specifically, catalyzes the posttranslational formation of 4-hydroxyproline in HIF alpha proteins. It hydroxylates HIF-1 alpha at Pro(402) and Pro(564), and HIF-2 alpha. It targets HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitylation complex.

UniProt: Q9GZT9

Pathways: cAMP Metabolic Process, Warburg Effekt