APG16L antikoerper, ATG16A antikoerper, ATG16L antikoerper, IBD10 antikoerper, WDR30 antikoerper, 1500009K01Rik antikoerper, Apg16l antikoerper, Atg16l antikoerper, Wdr30 antikoerper, atg16 antikoerper, atg16l antikoerper, fb57e05 antikoerper, wu:fb57e05 antikoerper, zgc:110147 antikoerper, autophagy related 16 like 1 antikoerper, autophagy related 16-like 1 (S. cerevisiae) antikoerper, autophagy related 16-like 1 antikoerper, autophagy related 16 like 1 S homeolog antikoerper, ATG16 autophagy related 16-like 1 (S. cerevisiae) antikoerper, ATG16L1 antikoerper, Atg16l1 antikoerper, atg16l1 antikoerper, atg16l1.S antikoerper
Hintergrund
ATG16L1/APG16L is part of a large protein complex that functions as a molecular scaffold mediating protein-protein interactions necessary for formation of the autophagosome in response to both classical and pathogen-related autophagy stimuli. APG16L protein contains an N-terminal Atg5-binding domain, a coiled-coil domain and a C-terminal WD (tryptophan-aspartic acid)-repeat domain. APG16L forms a complex with the Atg12 Atg5 conjugate and together they are actively translocated to the phagophore and are further elongated during autophagosome formation. Genetic variation in the APG16L gene has been recently implicated in Crohn's disease pathogenesis. Polymorphism within APG16L gene results in excessive production of IL-1beta and IL-6 culmunating in the inflammatory process in Crohn's disease.