SLC12A6 Antikörper (AA 401-500) (AbBy Fluor® 750)
-
- Target Alle SLC12A6 Antikörper anzeigen
- SLC12A6 (Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 6 (SLC12A6))
-
Bindungsspezifität
- AA 401-500
-
Reaktivität
- Human
-
Wirt
- Kaninchen
-
Klonalität
- Polyklonal
-
Konjugat
- Dieser SLC12A6 Antikörper ist konjugiert mit AbBy Fluor® 750
-
Applikation
- Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Homologie
- Human,Mouse,Rat,Cow,Sheep,Pig,Rabbit
- Aufreinigung
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human SLC12A6/KCC3
- Isotyp
- IgG
- Top Product
- Discover our top product SLC12A6 Primärantikörper
-
-
- Applikationshinweise
-
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
- Format
- Liquid
- Konzentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Konservierungsmittel
- ProClin
- Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Haltbarkeit
- 12 months
-
- Target
- SLC12A6 (Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 6 (SLC12A6))
- Andere Bezeichnung
- SLC12A6/KCC3 (SLC12A6 Produkte)
- Synonyme
- Kcc3 antikoerper, ACCPN antikoerper, KCC3 antikoerper, KCC3A antikoerper, KCC3B antikoerper, 9530023I19Rik antikoerper, gaxp antikoerper, solute carrier family 12, member 6 antikoerper, solute carrier family 12 member 6 antikoerper, Slc12a6 antikoerper, SLC12A6 antikoerper
- Hintergrund
-
Synonyms: ACCPN, Furosemide sensitive KCl cotransporter 3, Gaxp, KCC 3, KCC 3A, KCC 3B, KCC3 A, KCC3, KCC3 B, KCC3A, KCC3B, Potassium chloride cotransporter 3, Potassium chloride cotransporter KCC3a S3, SLC12 A6, SLC12A 6, Solute carrier family 12 potassium/chloride transporters, member 6, Solute carrier family 12, member 6, S12A6_HUMAN.
Background: The four isoforms of potassium/chloride co-transport channels (KCC) belong to a superfamily of cation-chloride co-transporters involved in cell volume maintenance. Nitric oxide (NO) donors activate KCCs, while inhibitors of the cGMP pathway prevent NO donor activation. The ubiquitously expressed KCC1 contains 12 transmembrane domains with both cytoplasmic N and C terminal domains. KCC2 expression is limited to neuronal tissues by a restrictive element similar to the neuronal-restrictive silencing factor. In neurons, KCC2 expression is correlated with an inhibitory response to GABA, while the absence of KCC2 is necessary for an unusual excitatory response to GABA. Alterations of KCC2 expression in the inferior colliculus of rat brain may be related to seizure susceptibility. Conversely, KCC3 is not suspected to play a major role in epilepsy. The two splice variants of KCC3, KCC3a and KCC3b, are predominantly expressed in brain and kidney, respectively, while KCC4 is expressed in muscle, brain, lung, heart and kidney.
-