TR4 Antikörper (AA 501-596) (AbBy Fluor® 680)
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- Target Alle TR4 (NR2C2) Antikörper anzeigen
- TR4 (NR2C2) (Nuclear Receptor Subfamily 2, Group C, Member 2 (NR2C2))
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Bindungsspezifität
- AA 501-596
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Reaktivität
- Maus
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser TR4 Antikörper ist konjugiert mit AbBy Fluor® 680
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Applikation
- Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Spezifität
- This antibody may have a minor secondary cross-reactivity towards NR2C1 in human and rat, based upon a non-sequential 77 % sequence similarity over the immunogen range.
- Kreuzreaktivität
- Maus
- Homologie
- Human,Rat,Dog,Cow,Horse,Chicken,Rabbit
- Aufreinigung
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human NR2C2/TAK1
- Isotyp
- IgG
- Top Product
- Discover our top product NR2C2 Primärantikörper
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- Applikationshinweise
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Konservierungsmittel
- ProClin
- Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Haltbarkeit
- 12 months
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- Target
- TR4 (NR2C2) (Nuclear Receptor Subfamily 2, Group C, Member 2 (NR2C2))
- Andere Bezeichnung
- NR2C2/TAK1 (NR2C2 Produkte)
- Synonyme
- TAK1 antikoerper, TR2R1 antikoerper, TR4 antikoerper, hTAK1 antikoerper, Tr4 antikoerper, gb:dq017625 antikoerper, im:6911408 antikoerper, mKIAA4145 antikoerper, nuclear receptor subfamily 2 group C member 2 antikoerper, nuclear receptor subfamily 2, group C, member 2 antikoerper, NR2C2 antikoerper, Nr2c2 antikoerper, nr2c2 antikoerper
- Hintergrund
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Synonyms: TR4, TAK1, Nuclear receptor subfamily 2 group C member 2, Orphan nuclear receptor TAK1, Orphan nuclear receptor TR4, Testicular receptor 4, NR2C2
Background: Orphan nuclear receptor that can act as a repressor or activator of transcription. An important repressor of nuclear receptor signaling pathways such as retinoic acid receptor, retinoid X, vitamin D3 receptor, thyroid hormone receptor and estrogen receptor pathways. May regulate gene expression during the late phase of spermatogenesis. Together with NR2C1, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription including that of GATA1. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Plays a fundamental role in early embryonic development and embryonic stem cells. Required for normal spermatogenesis and cerebellum development. Appears to be important for neurodevelopmentally regulated behavior (By similarity). Activates transcriptional activity of LHCG. Antagonist of PPARA-mediated transactivation.
- Gen-ID
- 7182
- UniProt
- P49116
- Pathways
- T-Zell Rezeptor Signalweg, Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Tube Formation, Toll-Like Receptors Cascades
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