TR4 Antikörper (pSer192)

Produktnummer ABIN802023

Produktdetails anti-TR4 Antikörper

Target: TR4 (NR2C2) (Nuclear Receptor Subfamily 2, Group C, Member 2 (NR2C2))

Bindungsspezifität: pSer192

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TR4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro))

Kreuzreaktivität: Human, Ratte

Homologie: Mouse,Cow,Pig,Horse,Chicken,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human TAK1 around the phosphorylation site of Ser192

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-TR4 Antikörper (ABIN802023)

Su, Zhou, Wang, Yang, Li, Yu, Li: "The PPARβ/δ agonist GW501516 attenuates peritonitis in peritoneal fibrosis via inhibition of TAK1-NFκB pathway in rats." in: Inflammation, Vol. 37, Issue 3, pp. 729-37, (2014) (PubMed).

Details zu TR4

Target: TR4 (NR2C2) (Nuclear Receptor Subfamily 2, Group C, Member 2 (NR2C2))

Andere Bezeichnung: TAK1 (NR2C2 Produkte)

Synonyme: TAK1 antikoerper, TR2R1 antikoerper, TR4 antikoerper, hTAK1 antikoerper, Tr4 antikoerper, gb:dq017625 antikoerper, im:6911408 antikoerper, mKIAA4145 antikoerper, nuclear receptor subfamily 2 group C member 2 antikoerper, nuclear receptor subfamily 2, group C, member 2 antikoerper, NR2C2 antikoerper, Nr2c2 antikoerper, nr2c2 antikoerper

Hintergrund:

Synonyms: MAP3K7phospho S192, M3K7_HUMAN, MAP3K 7, Map3k7, MEKK7, Mitogen activated protein kinase kinase kinase 7, Mitogen-activated protein kinase kinase kinase 7, Mitogen-activated protein kinase kinase kinase 7, TAK1, TGF beta activated kinase 1, TGF-beta-activated kinase 1, TGF1a, Transforming growth factor beta activated kinase 1, Transforming growth factor-beta-activated kinase 1.

Background: TAK1 (or MAP3K7) was shown to participate in regulation of transcription by transforming growth factor beta (TGF beta). TAK1 is stimulated in response to TGF beta and bone morphogenetic protein. These results suggest that TAK1 functions as a mediator in the signaling pathway of TGF beta superfamily members. TAB1 and TAB2 are TAK1 binding proteins that may function as activators of the TAK1 (TGF b activated kinase 1) MAPKKK in TGF b signal transduction. TAB1 induced TAK1 activation promoted the dissociation of active forms of IKKa and IKK b from active TAK1, whereas the IKK mutants remained to interact with active TAK1. TNF a activated endogenous TAK1, and the kinase negative TAK1 acted as a dominant negative inhibitor against TNF a induced NFkB activation. TAK1 was suggested to act as a regulatory kinase of IKKs.

Gen-ID: 7182

Pathways: T-Zell Rezeptor Signalweg, Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Tube Formation, Toll-Like Receptors Cascades