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Tuberin Antikörper (pSer1254)
TSC2
Reaktivität: Human
IHC (p)
Wirt: Kaninchen
Polyclonal
unconjugated
Produktdetails anti-Tuberin Antikörper
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Target
Alle Tuberin (TSC2) Antikörper anzeigen
Tuberin (TSC2)
(Tuberous Sclerosis 2 (TSC2))
Bindungsspezifität
Alle Epitope für Tuberin Antikörper
pSer1254
Reaktivität
Alle Reaktivitäten für Tuberin Antikörper
Human
Wirt
Alle Wirte für Tuberin Antikörper
Kaninchen
Klonalität
Alle Klonalitäten für Tuberin Antikörper
Polyklonal
Konjugat
Alle Konjugate für Tuberin Antikörper
Dieser Tuberin Antikörper ist unkonjugiert
Applikation
Alle Applikationen für Tuberin Antikörper
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Spezifität
This antibody detects endogenous levels of p-Tsc2 protein only when phosphorylated at Ser1254.
Kreuzreaktivität (Details)
Species reactivity (tested):Human.
Aufreinigung
Affinity chromatography
Reinheit
> 95 % by SDS-PAGE
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Anwendungsinformationen
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Applikationshinweise
Immunohistochemistry: 1/50 - 1/200. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Handhabung
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Konzentration
1,0 mg/mL
Buffer
Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung
Avoid repeated freezing and thawing.
Lagerung
4 °C/-20 °C
Informationen zur Lagerung
Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Details zu Tuberin
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Target
Tuberin (TSC2)
(Tuberous Sclerosis 2 (TSC2))
Andere Bezeichnung
Tuberin / TSC2 (TSC2 Produkte )
Synonyme
TSC2 antikoerper, fc16b02 antikoerper, tuberin antikoerper, wu:fc16b02 antikoerper, LAM antikoerper, TSC4 antikoerper, Nafld antikoerper, Tcs2 antikoerper, Rc antikoerper, TSC complex subunit 2 antikoerper, tuberin antikoerper, hypothetical protein antikoerper, tuberous sclerosis 2 antikoerper, TSC2 antikoerper, LOC5569538 antikoerper, tsc2 antikoerper, PGTG_00159 antikoerper, Tsc2 antikoerper
Hintergrund
Tuberin, or TSC2 (Tuberous sclerosis complex), is implicated as a tumor suppressor. It may function in vesicular transport, and may also play a role in the regulation of cell growth arrest and in the regulation of transcription mediated by steroid receptors. Interaction between hamartin (TSC1) and tuberin may facilitate vesicular docking. It specifically stimulates the intrinsic GTPase activity of the Ras related protein RAP1A and RAB5, suggesting a possible mechanism for its role in regulating cellular growth. Mutations in tuberin lead to constitutive activation of RAP1A in tumors. At least three isoforms of Tuberin exist.Synonyms: TSC4, Tuberous sclerosis 2 protein
Molekulargewicht
approx. 200 kDa
Gen-ID
7249
NCBI Accession
NP_000539
UniProt
P49815
Pathways
RTK Signalweg , AMPK Signaling , Fc-epsilon Rezeptor Signalübertragung , EGFR Signaling Pathway , Neurotrophin Signalübertragung , Regulation of Cell Size , Tube Formation , Protein targeting to Nucleus
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