Stathmin 1 Antikörper (pSer25)

Produktnummer ABIN498736

Produktdetails anti-Stathmin 1 Antikörper

Target: Stathmin 1 (STMN1)

Bindungsspezifität: pSer25

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Stathmin 1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Spezifität: This antibody detects endogenous levels of Op18 protein only when phosphorylated at Ser25.

Kreuzreaktivität (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Aufreinigung: Affinity chromatography

Reinheit: > 95 % by SDS-PAGE

Anwendungsinformationen

Applikationshinweise: Western Blot: 1/500 - 1/1000. Immunohistochemistry: 1/50 - 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS, pH 7.2., 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu Stathmin 1

Target: Stathmin 1 (STMN1)

Andere Bezeichnung: Stathmin / STMN1 (STMN1 Produkte)

Synonyme: C1orf215 antikoerper, LAP18 antikoerper, Lag antikoerper, OP18 antikoerper, PP17 antikoerper, PP19 antikoerper, PR22 antikoerper, SMN antikoerper, 19k antikoerper, Lap18 antikoerper, Op18 antikoerper, P18 antikoerper, P19 antikoerper, Pig antikoerper, Pp17 antikoerper, Pp18 antikoerper, Pp19 antikoerper, Pr22 antikoerper, Smn antikoerper, prosolin antikoerper, op18 antikoerper, stathmin antikoerper, stmn1 antikoerper, stmn1a antikoerper, lag antikoerper, lap18 antikoerper, pp17 antikoerper, pp19 antikoerper, pr22 antikoerper, smn antikoerper, fj43c10 antikoerper, wu:fj38b07 antikoerper, wu:fj43c10 antikoerper, zgc:110159 antikoerper, cb959 antikoerper, wu:fb14e04 antikoerper, zgc:136942 antikoerper, stmn1-a antikoerper, stmn1b antikoerper, xo35 antikoerper, stathmin 1 antikoerper, stathmin 1 S homeolog antikoerper, stathmin 1b antikoerper, stathmin 1a antikoerper, stathmin-like antikoerper, stathmin antikoerper, stathmin 1 L homeolog antikoerper, STMN1 antikoerper, Stmn1 antikoerper, stmn1.S antikoerper, stmn1 antikoerper, stmn1b antikoerper, stmn1a antikoerper, LOC100229194 antikoerper, stmn1.L antikoerper

Hintergrund: Oncoprotein 18 (Op18) is a regulator of microtubule (MT) dynamics. Op18 is a target for both cell cycle and cell surface receptor-coupled kinase systems, and phosphorylation of Op18 on specific combinations of amino acid residues has been shown to switch off MT-destabilizing activity of Op18. Induced expression of the catalytic subunit of cAMPdependent protein kinase (PKA) results in a dramatic increase in cellular MT polymer content concomitant with phosphorylation and partial degradation of Op18. Phosphorylation of Op18 on two specific sites, Serine 16 and Serine 63, is necessary and sufficient for PKA to switch off Op18 activity in intact cells. PKA phosphorylation down-regulates the MT-destabilizing activity of Op18, which in turn promotes increased Tubulin polymerization. Op18 has the potential to regulate the MT system in response to external signals such as cAMP-linked agonists.Synonyms: LAP18, Leukemia-associated phosphoprotein p18, Metablastin, OP18, Oncoprotein 18, Op18, Phosphoprotein p19, Prosolin, Protein Pr22, pp17, pp19

Molekulargewicht: approx. 19 kDa

Gen-ID: 3925

NCBI Accession: NP_005554

UniProt: P16949

Pathways: MAPK Signalweg, Microtubule Dynamics