Glutamate Receptor 1 Antikörper

Produktnummer ABIN498650

Produktdetails anti-Glutamate Receptor 1 Antikörper

Target: Glutamate Receptor 1 (GLUR1)

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Glutamate Receptor 1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Spezifität: This antibody detects endogenous levels of GluR1 protein. (region surrounding Ser857)

Kreuzreaktivität (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Aufreinigung: Affinity Chromatography using epitope-specific immunogen

Anwendungsinformationen

Applikationshinweise: Western Blot: 1/500 - 1/1000. Immunohistochemistry: 1/50 - 1/200. Immunofluorescence: 1/50 - 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH ~7.2, 0.05 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu Glutamate Receptor 1

Target: Glutamate Receptor 1 (GLUR1)

Andere Bezeichnung: Glutamate Receptor 1 / GLUR1 (GLUR1 Produkte)

Synonyme: GLUH1 antikoerper, GLUR1 antikoerper, GLURA antikoerper, GluA1 antikoerper, HBGR1 antikoerper, gluR-A antikoerper, 2900051M01Rik antikoerper, Glr-1 antikoerper, Glr1 antikoerper, GluR-A antikoerper, GluRA antikoerper, Glur-1 antikoerper, Glur1 antikoerper, HIPA1 antikoerper, gluR-K1 antikoerper, GRIA1 antikoerper, glur1 antikoerper, Gria1 antikoerper, glur1b antikoerper, gria1.2 antikoerper, sb:eu293 antikoerper, ZfGluR1a antikoerper, glur1a antikoerper, gria1.1 antikoerper, zfGRIA1[a] antikoerper, glutamate ionotropic receptor AMPA type subunit 1 antikoerper, glutamate receptor, ionotropic, AMPA1 (alpha 1) antikoerper, glutamate receptor, ionotropic, AMPA 1 antikoerper, glutamate receptor, ionotropic, AMPA 1 L homeolog antikoerper, GluR1 protein antikoerper, Glutamate receptor 1 antikoerper, glutamate receptor, ionotropic, AMPA 1b antikoerper, glutamate receptor, ionotropic, AMPA 1a antikoerper, GRIA1 antikoerper, Gria1 antikoerper, gria1 antikoerper, gria1.L antikoerper, glur1 antikoerper, glr-1 antikoerper, gria1b antikoerper, gria1a antikoerper

Hintergrund: Glutamate receptors mediate most excitatory neurotransmission in the brain and play an important role in neural plasticity, neural development and neurodegeneration. Ionotropic glutamate receptors are categorized into NMDA receptors and kainate/AMPA receptors, both of which contain glutamategated, caution-specific ion channels. Kainate/AMPA receptors are co-localized with NMDA receptors in many synapses and consist of seven structurally related subunits designated GluR-1 to -7. The kainate/AMPA receptors are primarily responsible for the fast excitatory neurotransmission by glutamate whereas the NMDA receptors are functionally characterized by a slow kinetic and a high permeability for Ca2+ ions. The NMDA receptors consist of five subunits: epsilion 1, 2, 3, 4 and one zeta subunit. The zeta subunit is expressed throughout the brainstem whereas the four epsilon subunits display limited distribution.Synonyms: AMPA-selective glutamate receptor 1, AMPA1, GLUH1, GRIA1, GluR-1, GluR-A, GluR-K1, Glutamate receptor ionotropic

Molekulargewicht: approx. 102 kDa

Gen-ID: 2890

NCBI Accession: NP_000818

UniProt: P42261

Pathways: PI3K-Akt Signalweg