Glutamate Receptor 1 Antikörper (AA 19-360)

Produktnummer ABIN3043837

Produktdetails anti-Glutamate Receptor 1 Antikörper

Target: Glutamate Receptor 1 (GLUR1)

Bindungsspezifität: AA 19-360

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Glutamate Receptor 1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Verwendungszweck: Rabbit IgG polyclonal antibody for Glutamate receptor 1(GRIA1) detection. Tested with WB, IHC-P in Human,Mouse,Rat.

Kreuzreaktivität (Details): No cross reactivity with other proteins.

Produktmerkmale: Rabbit IgG polyclonal antibody for Glutamate receptor 1(GRIA1) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
Gene Name: glutamate receptor, ionotropic, AMPA 1
Protein Name: Glutamate receptor 1

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human GRIA1 recombinant protein (Position: A19-R360). Human GRIA1 shares 98% amino acid (aa) sequence identity with both mouse and rat GRIA1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Mouse, Rat, The detection limit for GRIA1 is approximately 0.25 ng/lane under reducing conditions.
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Mouse, Rat, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Referenzen für anti-Glutamate Receptor 1 Antikörper (ABIN3043837)

Liu, Mei, Li, Roboti, Pang, Ying, Gao, Lowe, Bao: "Loss of the golgin GM130 causes Golgi disruption, Purkinje neuron loss, and ataxia in mice." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 114, Issue 2, pp. 346-351, (2018) (PubMed).

Details zu Glutamate Receptor 1

Target: Glutamate Receptor 1 (GLUR1)

Andere Bezeichnung: GRIA1 (GLUR1 Produkte)

Synonyme: GLUH1 antikoerper, GLUR1 antikoerper, GLURA antikoerper, GluA1 antikoerper, HBGR1 antikoerper, gluR-A antikoerper, 2900051M01Rik antikoerper, Glr-1 antikoerper, Glr1 antikoerper, GluR-A antikoerper, GluRA antikoerper, Glur-1 antikoerper, Glur1 antikoerper, HIPA1 antikoerper, gluR-K1 antikoerper, GRIA1 antikoerper, glur1 antikoerper, Gria1 antikoerper, glur1b antikoerper, gria1.2 antikoerper, sb:eu293 antikoerper, ZfGluR1a antikoerper, glur1a antikoerper, gria1.1 antikoerper, zfGRIA1[a] antikoerper, glutamate ionotropic receptor AMPA type subunit 1 antikoerper, glutamate receptor, ionotropic, AMPA1 (alpha 1) antikoerper, glutamate receptor, ionotropic, AMPA 1 antikoerper, glutamate receptor, ionotropic, AMPA 1 L homeolog antikoerper, GluR1 protein antikoerper, Glutamate receptor 1 antikoerper, glutamate receptor, ionotropic, AMPA 1b antikoerper, glutamate receptor, ionotropic, AMPA 1a antikoerper, GRIA1 antikoerper, Gria1 antikoerper, gria1 antikoerper, gria1.L antikoerper, glur1 antikoerper, glr-1 antikoerper, gria1b antikoerper, gria1a antikoerper

Hintergrund: GLUR1, Glutamate receptor 1, is a protein that in humans is encoded by the GLUR1 gene. GLUR1 mRNA is widely expressed in human brain. Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The GRIA1 belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. Each of the members (GRIA1-4) include flip and flop isoforms generated by alternative RNA splicing. The receptor subunits encoded by each isoform vary in their signal transduction properties. The isoform presented here is the flop isoform. In situ hybridization experiments showed that human GRIA1 mRNA is present in granule and pyramidal cells in the hippocampal formation.

Synonyms: GLUR 1 antibody|GLUR A antibody|AMPA 1 antibody|AMPA selective glutamate receptor 1 antibody|AMPA-selective glutamate receptor 1 antibody|GluA1 antibody|GLUH 1 antibody|GLUH1 antibody|GluR K1 antibody|GluR-1 antibody|GluR-A antibody|GluR-K1 antibody|GLUR1 antibody|GLURA antibody|GluRK1 antibody|Glutamate receptor 1 antibody|Glutamate receptor ionotropic AMPA 1 antibody|Glutamate receptor ionotropic antibody|Glutamate receptor, ionotropic, AMPA 1 antibody|Gria 1 antibody|Gria1 antibody|GRIA1_HUMAN antibody|HBGR1 antibody|MGC133252 antibody|OTTHUMP00000160643 antibody|OTTHUMP00000165781 antibody|OTTHUMP00000224241 antibody|OTTHUMP00000224242 antibody|OTTHUMP00000224243 antibody

Gen-ID: 2890

UniProt: P42261

Pathways: PI3K-Akt Signalweg