HIF3A Antikörper

Produktnummer ABIN498504

Produktdetails anti-HIF3A Antikörper

Target: HIF3A (Hypoxia Inducible Factor 3, alpha Subunit (HIF3A))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HIF3A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Spezifität: This antibody detects endogenous levels of HIF-3alpha protein. (region surrounding Glu354)

Kreuzreaktivität (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Aufreinigung: Affinity chromatography

Reinheit: > 95 % by SDS-PAGE

Anwendungsinformationen

Applikationshinweise: Western Blot: 1/500 - 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2., 0.05 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu HIF3A

Target: HIF3A (Hypoxia Inducible Factor 3, alpha Subunit (HIF3A))

Andere Bezeichnung: HIF3A / HIF3 alpha (HIF3A Produkte)

Synonyme: HIF-3A antikoerper, IPAS antikoerper, MOP7 antikoerper, PASD7 antikoerper, bHLHe17 antikoerper, Ipas antikoerper, NEPAS antikoerper, Mop7 antikoerper, HIF3A antikoerper, hypoxia inducible factor 3 alpha subunit antikoerper, hypoxia inducible factor 3, alpha subunit antikoerper, HIF3A antikoerper, Hif3a antikoerper

Hintergrund: Cell growth and viability is compromised by oxygen deprivation (hypoxia). Hypoxia-inducible factors, including HIF-1α, HIF-1β (also designated Arnt 1), EPAS-1 (also designated HIF-2α) and HIF-3α, induce glycolysis, erythropoiesis and angiogenesis in order to restore oxygen homeostasis. Hypoxia-inducible factors are members of the Per-Arnt-Sim (PAS) domain transcription factor family. In response to hypoxia, HIF-1α is upregulated and forms a heterodimer with Arnt 1 to form the HIF-1 complex. The HIF-1 complex recognizes and binds to the hypoxia responsive element (HRE) of hypoxia-inducible genes, thereby activating transcription.Synonyms: BHLHE17, Basic-helix-loop-helix-PAS protein MOP7, Class E basic helix-loop-helix protein 17, HIF-3 alpha, Hypoxia-inducible factor 3 alpha, IPAS, Inhibitory PAS domain protein, MOP7, Member of PAS protein 7, PASD7

Molekulargewicht: approx. 65 kDa

Gen-ID: 64344

NCBI Accession: NP_071907

UniProt: Q9Y2N7

Pathways: Warburg Effekt