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HIF3A Antikörper (AA 581-592)

HIF3A Reaktivität: Maus WB, ELISA Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN100475
  • Target Alle HIF3A Antikörper anzeigen
    HIF3A (Hypoxia Inducible Factor 3, alpha Subunit (HIF3A))
    Bindungsspezifität
    • 6
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 581-592
    Reaktivität
    • 29
    • 15
    • 13
    • 1
    Maus
    Wirt
    • 26
    • 4
    • 1
    Kaninchen
    Klonalität
    • 30
    • 1
    Polyklonal
    Konjugat
    • 20
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser HIF3A Antikörper ist unkonjugiert
    Applikation
    • 18
    • 10
    • 10
    • 5
    • 2
    • 2
    Western Blotting (WB), ELISA
    Produktmerkmale
    Concentration Definition: by UV absorbance at 280 nm
    Sterilität
    Sterile filtered
    Immunogen
    This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to aa 581-592 of mouse Hif3 a (Hypoxia Inducible Factor).
    Isotyp
    IgG
    Top Product
    Discover our top product HIF3A Primärantikörper
  • Applikationshinweise
    This affinity-purified antibody has been tested for use in ELISA and western blot.  Specific conditions for reactivity should be optimized by the end user. Expect a band approximately 72 kDa in size corresponding to Hif3 a protein by western blotting in the appropriate cell lysate or extract. This antibody is expected to cross-react with mouse and rat Hif3 a due to sequence homology.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1.2 mg/mL
    Buffer
    0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
  • Takeda, Ho, Takeda, Duan, Nagy, Fong: "Placental but not heart defects are associated with elevated hypoxia-inducible factor alpha levels in mice lacking prolyl hydroxylase domain protein 2." in: Molecular and cellular biology, Vol. 26, Issue 22, pp. 8336-46, (2006) (PubMed).

  • Target
    HIF3A (Hypoxia Inducible Factor 3, alpha Subunit (HIF3A))
    Andere Bezeichnung
    HIF3 alpha (HIF3A Produkte)
    Synonyme
    HIF-3A antikoerper, IPAS antikoerper, MOP7 antikoerper, PASD7 antikoerper, bHLHe17 antikoerper, Ipas antikoerper, NEPAS antikoerper, Mop7 antikoerper, HIF3A antikoerper, hypoxia inducible factor 3 alpha subunit antikoerper, hypoxia inducible factor 3, alpha subunit antikoerper, HIF3A antikoerper, Hif3a antikoerper
    Hintergrund
    One of the most important factors in the cellular response to hypoxia is hypoxia-inducible factor (HIF), which transcriptionally activates genes encoding proteins that mediate adaptive responses to reduced oxygen availability. HIF is a heterodimer consisting of one of three PRIVATE ''TYPE=PICT;ALT={alpha}''subunits (HIF1-aPRIVATE ''TYPE=PICT;ALT={alpha}'', HIF2-a,PRIVATE ''TYPE=PICT;ALT={alpha}'' or HIF3-a)PRIVATE ''TYPE=PICT;ALT={alpha}'' bound to the aryl hydrocarbon receptor nuclear translocator (ARNT) that is also known as HIF1-b. HIF-aPRIVATE ''TYPE=PICT;ALT={alpha}'' is a member of the basic helix-loop-helix (bHLH) superfamily, in which the HLH domain mediates subunit dimerization while the basic domain binds to DNA. HIF target genes play critical roles in metabolism, angiogenesis, cell proliferation, and cell survival; in fact, HIF3-a may be a marker for tumor growth and angiogenesis . Examples of HIF target genes include VEGF, glucose transporter 1 (GLUT1), and EPO. HIF binds to the hypoxia-responsive
    Synonyms: HIF3 alpha antibody, HIF3A antibody, Hypoxia Inducible Factor 3 alpha antibody, Hypoxia inducible factor 3 alpha subunit antibody, Hypoxia inducible factor three alpha antibody, Inhibitory PAS domain protein antibody, IPAS antibody
    Gen-ID
    53417, 170295859
    UniProt
    Q0VBL6
    Pathways
    Warburg Effekt
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