GRB10 Antikörper

Produktnummer ABIN498201

Produktdetails anti-GRB10 Antikörper

Target: GRB10 (Growth Factor Receptor-Bound Protein 10 (GRB10))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GRB10 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Spezifität: This antibody detects endogenous levels of GRB10 protein. (region surrounding Leu63)

Kreuzreaktivität (Details): Species reactivity (tested):Human.

Aufreinigung: Affinity chromatography using epitope-specific immunogen

Reinheit: > 95 % (by SDS-PAGE)

Anwendungsinformationen

Applikationshinweise: Western blot: 1: 500 - 1: 1000. Immunohistochemistry on paraffin sections: 1: 50 - 1: 200. Immunoflourescence: 1: 50 - 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS) with 0.05 % sodium azide, approx. pH 7.2

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Details zu GRB10

Target: GRB10 (Growth Factor Receptor-Bound Protein 10 (GRB10))

Andere Bezeichnung: GRB10 / GRBIR (GRB10 Produkte)

Synonyme: grb10 antikoerper, zgc:91987 antikoerper, GRB10 antikoerper, grb-10 antikoerper, grb-ir antikoerper, irbp antikoerper, meg1 antikoerper, rss antikoerper, LOC100224775 antikoerper, 5730571D09Rik antikoerper, AI325020 antikoerper, Meg1 antikoerper, mKIAA0207 antikoerper, RGD1566234 antikoerper, GRB-IR antikoerper, Grb-10 antikoerper, IRBP antikoerper, MEG1 antikoerper, RSS antikoerper, growth factor receptor bound protein 10 antikoerper, growth factor receptor-bound protein 10a antikoerper, growth factor receptor bound protein 10 L homeolog antikoerper, growth factor receptor-bound protein 10 antikoerper, GRB10 antikoerper, grb10a antikoerper, grb10 antikoerper, grb10.L antikoerper, LOC100434903 antikoerper, Grb10 antikoerper

Hintergrund: Many growth factors function by binding receptors with intrinsic tyrosine kinase activity. Signaling by such receptors involves a series of intermediates characterized by SH2 domains that bind tyrosine phosphorylated receptors by a direct interaction between the SH2 domain and specific phosphotyrosine- containing receptor sequences. GRB7, a SH2 domain protein, has a single SH2 domain at its C-terminal, a central region with similarity to Ras GAP, and a proline-rich N terminus. A related SH2 domain-containing protein, GRB10, exhibits a high degree of homology with GRB7. GRB10 undergoes serine but not tyrosine phosphorylation in response to EGF treatment, but appears to bind to the EGF receptor poorly. GRB10 maps to mouse chromosome 11, in close proximity to the EGF receptor. Similarly, GRB7 maps to the same mouse chromosome near the EGF receptor-related protein HER2.Synonyms: Grb-IR, Growth factor receptor-bound protein 10, Insulin receptor-binding protein Grb-IR, KIAA0207

Molekulargewicht: approx. 67 kDa

Gen-ID: 2887

NCBI Accession: NP_001001549

UniProt: Q13322

Pathways: Regulation of Carbohydrate Metabolic Process, Signaling Events mediated by VEGFR1 and VEGFR2